{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:03:30Z","timestamp":1790283810257,"version":"4.1.0"},"reference-count":0,"publisher":"Annual Reviews","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:p>Maternal vascular adaptations to pregnancy optimize uterine and fetoplacental perfusion. When vascular remodeling and\/or function are impaired, the maternal circulation may fail to meet the physiological demands of pregnancy, thereby increasing the risk of complications. The most common complications of pregnancy affecting maternal vascular health include hypertensive disorders of pregnancy, particularly preeclampsia; infectious or autoimmune diseases that often induce a preeclampsia-like phenotype; metabolic disorders such as gestational diabetes mellitus and excessive hypercholesterolemia; and advanced maternal age. Moreover, women with a history of a complicated pregnancy have an increased risk of developing later-life cardiovascular disease, representing a sex-specific risk factor. This review summarizes the mechanisms underlying vascular adaptations to pregnancy and examines how abnormal vascular changes within and beyond the uteroplacental circulation contribute to the development of pregnancy complications, as well as how these complications, in turn, affect maternal vascular health during pregnancy and later in life, focusing on underlying mechanisms.<\/jats:p>","DOI":"10.1146\/annurev-physiol-040425-100711","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:41:09Z","timestamp":1790282469000},"source":"Crossref","is-referenced-by-count":0,"title":["Vascular Physiology and Pregnancy Complications"],"prefix":"10.1146","author":[{"given":"Amanda A.","family":"de Oliveira","sequence":"first","affiliation":[{"name":"1Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada; email:\u00a0sandra.davidge@ualberta.ca"},{"name":"2Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"Bertagnolli","sequence":"additional","affiliation":[{"name":"3Cardiovascular Health Across the Lifespan Program, Research Institute of the McGill University Health Centre, Montr\u00e9al, Qu\u00e9bec, Canada"},{"name":"4School of Physical and Occupational Therapy, Faculty of Medicine and Health Sciences, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra T.","family":"Davidge","sequence":"additional","affiliation":[{"name":"1Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada; email:\u00a0sandra.davidge@ualberta.ca"},{"name":"2Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada"},{"name":"5Department of Physiology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","container-title":["Annual Review of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annualreviews.org\/content\/journals\/10.1146\/annurev-physiol-040425-100711?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:41:09Z","timestamp":1790282469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annualreviews.org\/content\/journals\/10.1146\/annurev-physiol-040425-100711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1146\/annurev-physiol-040425-100711","relation":{},"ISSN":["0066-4278","1545-1585"],"issn-type":[{"value":"0066-4278","type":"print"},{"value":"1545-1585","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}