{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:53:38Z","timestamp":1774666418116,"version":"3.50.1"},"reference-count":32,"publisher":"Annual Reviews","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annu. Rev. Med."],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p> \u25aa Abstract\u2002 Two important types of antineutrophil cytoplasmic antibodies (ANCA) have been identified: anti-proteinase 3 and anti-myeloperoxidase antibodies. In the appropriate clinical setting, the presence of either is virtually diagnostic of the subset of vasculitis that includes Wegener's granulomatosis, microscopic polyangiitis (microscopic polyarteritis), the Churg-Strauss syndrome, idiopathic pauci-immune necrotizing and crescentic glomerulonephritis, and related and overlapping forms of these vasculitidies. The finding of ANCA throughout this group identifies these syndromes as belonging to a single category or spectrum of disease. <\/jats:p>","DOI":"10.1146\/annurev.med.47.1.303","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"303-313","source":"Crossref","is-referenced-by-count":39,"title":["ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN THE CLASSIFICATION OF VASCULITIS"],"prefix":"10.1146","volume":"47","author":[{"given":"John L.","family":"Niles, M.D","sequence":"first","affiliation":[{"name":"Renal Unit, Department of Medicine, and Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6342.606"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1984.tb03769.x"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91147-X"},{"key":"b4","first-page":"350","volume":"69","author":"L\u00fcdemann G","year":"1987","journal-title":"Clin. Exp. Immunol."},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90591-5"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806233182504"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.6.1888.1888"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.48"},{"key":"b9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1681\/ASN.V2127","volume":"2","author":"Niles JL","year":"1991","journal-title":"J. Am. Soc. Nephrol."},{"key":"b10","first-page":"517","volume":"118","author":"Bosch X","year":"1994","journal-title":"Arch. Pathol. Lab. Med."},{"key":"b11","unstructured":"Niles JL, McCluskey RT. 1995. Vasculitis. InDiagnostic Immunopathology, ed. RB Colvin, AK Bhan, RT McCluskey, pp. 95\u2013108. New York: Raven"},{"key":"b12","unstructured":"McCluskey RT, Collins AB, Niles JL. 1995. Renal diseases. InDiagnostic Immunopathology, ed. RB Colvin, AK Bhan, RT McCluskey, pp. 109\u201321. New York: Raven. 2nd ed."},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-1-28"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-1-76"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-488"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90295-R"},{"key":"b18","first-page":"467","volume":"56","author":"Savage CO","year":"1985","journal-title":"Q. J. Med."},{"key":"b19","unstructured":"Rosen S, Falk RJ, Jennette JC. 1991. Polyarteritis nodosa, including microscopic form and renal vasculitis. InSystemic Vasculitidies, ed. A Churg, J Churg, pp. 57\u201373. New York: Igaku-Shoin"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb06157.x"},{"key":"b21","unstructured":"Lanham JG, Churg J. 1991. Churg-Strauss syndrome. InSystemic Vasculitidies, ed. A Churg, J Churg, pp. 101\u201320. New York: Igaku-Shoin"},{"key":"b22","author":"Niles JL","year":"1995","journal-title":"Arch. Intern. Med."},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1991.tb00342.x"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91761-A"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.72"},{"key":"b26","first-page":"107","volume":"36","author":"Bosch X","year":"1991","journal-title":"Clin. Nephrol."},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb06160.x"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90074-8"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80695-0"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.149.11.2461"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4115"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.52"}],"container-title":["Annual Review of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annualreviews.org\/doi\/pdf\/10.1146\/annurev.med.47.1.303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T23:49:29Z","timestamp":1634168969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annualreviews.org\/doi\/10.1146\/annurev.med.47.1.303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1146\/annurev.med.47.1.303"],"URL":"https:\/\/doi.org\/10.1146\/annurev.med.47.1.303","relation":{},"ISSN":["0066-4219","1545-326X"],"issn-type":[{"value":"0066-4219","type":"print"},{"value":"1545-326X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}