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Reviewed here are various genetic engineering approaches that might help overcome these rejection factors, resulting eventually in a multi-transgene donor pig. Other concerns and current controversies in the field are also discussed.<\/jats:p>","DOI":"10.1146\/annurev.med.49.1.301","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"301-310","source":"Crossref","is-referenced-by-count":67,"title":["Xenotransplantation: Problems and Prospects"],"prefix":"10.1146","volume":"49","author":[{"suffix":"MD","given":"Fritz H.","family":"Bach","sequence":"first","affiliation":[{"name":"Lewis Thomas Professor, Harvard Medical School, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199411270-00001"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)10024-4"},{"key":"b3","first-page":"678","volume":"28","author":"Candinas D","year":"1996","journal-title":"Transplant. 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