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This review examines these data and the principles relevant to their interpretation and discusses the insights they provide into the anatomical correlates of depression. Within the anatomical networks implicated in emotional processing by other types of evidence, these BF and metabolic data demonstrate that major depression is associated with reversible, mood state\u2013dependent, neurophysiological abnormalities in some structures and irreversible, trait-like abnormalities in other structures. In some of the regions in which trait-like abnormalities appear, abnormal metabolic activity appears at least partly related to the anatomical abnormalities identified in magnetic resonance imaging (MRI) studies of depression. <\/jats:p>","DOI":"10.1146\/annurev.med.49.1.341","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"341-361","source":"Crossref","is-referenced-by-count":352,"title":["Functional Neuroimaging Studies of Depression: The Anatomy of Melancholia"],"prefix":"10.1146","volume":"49","author":[{"suffix":"MD","given":"Wayne C.","family":"Drevets","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"b1","unstructured":"Drevets WC, Todd RD. 1997. Depression, mania and related disorders. 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