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Most of these infections are hospital-acquired, and studies over the past several years suggest that they are often caused by strains that are transmitted among hospitalized patients. Other important infections due to coagulase-negative staphylococci include central nervous system shunt infections, native or prosthetic valve endocarditis, urinary tract infections, and endophthalmitis. Intravenous treatment of systemic infections is usually required because coagulase-negative staphylococci have become increasingly resistant to multiple antibiotics.<\/jats:p>","DOI":"10.1146\/annurev.med.50.1.223","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"223-236","source":"Crossref","is-referenced-by-count":331,"title":["Coagulase-Negative Staphylococci: Role as Pathogens"],"prefix":"10.1146","volume":"50","author":[{"given":"Johannes","family":"Huebner, MD","sequence":"first","affiliation":[{"name":"Dept. of Infectious Diseases, Children's Hospital, 2Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"Goldmann, MD","sequence":"additional","affiliation":[{"name":"Dept. of Infectious Diseases, Children's Hospital, 2Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1128\/jcm.1.1.82-88.1975","volume":"1","author":"Kloos WE","year":"1975","journal-title":"J. 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