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These properties must be understood and controlled if hemoglobin-based products are to fulfill their promise. The development of red cell substitutes affords us a deeper insight into how oxygen is delivered to tissues in the microcirculation and how blood-flow distribution is regulated within and between organs. As red cell substitutes become available to clinicians and scientists, clinical applications are expected to expand. <\/jats:p>","DOI":"10.1146\/annurev.med.50.1.337","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"337-353","source":"Crossref","is-referenced-by-count":87,"title":["New Transfusion Strategies: Red Cell Substitutes"],"prefix":"10.1146","volume":"50","author":[{"given":"Robert M.","family":"Winslow, MD","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, California 92161,"},{"name":"Department of Veterans Affairs Medical Center, San Diego, California 92161;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22","reference":[{"key":"b1","volume-title":"Hemoglobin-Based Red Cell Substitutes.","author":"Winslow RM","year":"1992"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(96)80003-4"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2576-8_7"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1986.tb02589.x"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(83)90157-7"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1139\/o78-153"},{"key":"b7","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1016\/S0021-9258(18)67605-7","volume":"261","author":"Chatterjee R","year":"1986","journal-title":"J. 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