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IL-6 is a potent mediator of inflammatory processes, and it has been proposed that the age-associated increase in IL-6 accounts for certain of the phenotypic changes of advanced age, particularly those that resemble chronic inflammatory disease [decreased lean body mass, osteopenia, low-grade anemia, decreased serum albumin and cholesterol, and increased inflammatory proteins such as C-reactive protein (CRP) and serum amyloid A]. Furthermore, the age-associated rise in IL-6 has been linked to lymphoproliferative disorders, multiple myeloma, osteoporosis, and Alzheimer\u2019s disease. This overview discusses the data relating IL-6 to age-associated diseases and to frailty. Like the syndrome of inappropriate antidiuretic hormone, it is possible that certain clinically important late-life changes are due to an inappropriate presence of IL-6.<\/jats:p>","DOI":"10.1146\/annurev.med.51.1.245","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"245-270","source":"Crossref","is-referenced-by-count":993,"title":["Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty"],"prefix":"10.1146","volume":"51","author":[{"given":"William B.","family":"Ershler","sequence":"first","affiliation":[{"name":"The Institute for the Advanced Studies in Aging and Geriatric Medicine, Washington DC, 20006;"},{"name":", Unit for Laboratory Animal Medicine, Department of Pathology, and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan T.","family":"Keller","sequence":"additional","affiliation":[{"name":"The Institute for the Advanced Studies in Aging and Geriatric Medicine, Washington DC, 20006;"},{"name":", Unit for Laboratory Animal Medicine, Department of Pathology, and Institute of Gerontology, University of Michigan, Ann Arbor, Michigan, 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"crossref","unstructured":"Ershler WB. 1993. 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