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Mutations in FBN1, the gene that encodes fibrillin-1, are responsible for MFS and (in a few patients) other disorders in the continuum. In addition to skeletal, ocular, and cardiovascular features, patients with MFS have involvement of the skin, integument, lungs, and muscle tissue. Over the past 30 years, evolution of aggressive medical and surgical management of the cardiovascular problems, especially mitral valve prolapse, aortic dilatation, and aortic dissection, has resulted in considerable improvement in life expectancy.<\/jats:p>","DOI":"10.1146\/annurev.med.51.1.481","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:45:04Z","timestamp":1027770304000},"page":"481-510","source":"Crossref","is-referenced-by-count":338,"title":["The Marfan Syndrome"],"prefix":"10.1146","volume":"51","author":[{"given":"Reed E.","family":"Pyeritz","sequence":"first","affiliation":[{"name":"Departments of Human Genetics, Medicine and Pediatrics, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania, 19102, ;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"crossref","unstructured":"McKusick VA. 1955. 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