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Subcutaneous inoculation of the HSV vectors can be used to transduce neurons of the dorsal root ganglion to provide a therapeutic effect in models of polyneuropathy and chronic regional pain. In human trials, direct injection of replication-competent HSV into brain tumors has proven safe. Human trials of nonreplicating HSV gene transfer by direct inoculation for treatment of glioblastoma and HSV gene transfer by subcutaneous inoculation for the treatment of chronic intractable pain should commence soon.<\/jats:p>","DOI":"10.1146\/annurev.micro.58.030603.123709","type":"journal-article","created":{"date-parts":[[2004,10,15]],"date-time":"2004-10-15T08:54:57Z","timestamp":1097830497000},"page":"253-271","source":"Crossref","is-referenced-by-count":97,"title":["Herpes Vector-Mediated Gene Transfer in Treatment of Diseases of the Nervous System"],"prefix":"10.1146","volume":"58","author":[{"given":"Joseph C.","family":"Glorioso","sequence":"first","affiliation":[{"name":"1Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Fink","sequence":"additional","affiliation":[{"name":"2Department of Neurology, University of Michigan, Ann Arbor, Michigan 48105;"},{"name":"3VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00247-2"},{"key":"B2","first-page":"1502","volume":"57","author":"Andreansky S","year":"1997","journal-title":"Cancer Res."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10099"},{"key":"B4","first-page":"3573","volume":"66","author":"Batterson W","year":"1983","journal-title":"J. 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