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In addition, we review our current understanding of the slit diaphragm (a specialized cell junction found in the kidney), slit diaphragm\u2013associated proteins (including nephrin, podocin, \u03b1-actinin-4, CD2-associated protein, and transient receptor potential channel 6), and the role of these proteins in glomerular disease. We also discuss the most recent research on the pathogenesis of collapsing glomerulosclerosis, human immunodeficiency virus associated nephropathy, Denys-Drash, diabetic nephropathy, Alport syndrome, and other diseases related to the interaction between the podocyte and the glomerular basement membrane. <\/jats:p>","DOI":"10.1146\/annurev.pathol.1.110304.100119","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T08:51:58Z","timestamp":1166172718000},"page":"349-374","source":"Crossref","is-referenced-by-count":58,"title":["PATHOGENESIS OF NONIMMUNE GLOMERULOPATHIES"],"prefix":"10.1146","volume":"1","author":[{"given":"Christopher","family":"Kwoh","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63113;, ,"},{"name":"Department of Immunology and Pathology, Washington University School of Medicine, St. Louis, Missouri 63113;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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