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This review describes recent connections between copper and PrP<jats:sup>C<\/jats:sup>, with an emphasis on the electron paramagnetic resonance elucidation of the specific copper-binding sites, insights into PrP<jats:sup>C<\/jats:sup> function, and emerging connections between copper and prion disease. <\/jats:p>","DOI":"10.1146\/annurev.physchem.58.032806.104657","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T16:33:06Z","timestamp":1162312386000},"page":"299-320","source":"Crossref","is-referenced-by-count":239,"title":["Copper and the Prion Protein: Methods, Structures, Function, and Disease"],"prefix":"10.1146","volume":"58","author":[{"given":"Glenn L.","family":"Millhauser","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1675487"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5336.245"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13363"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1025"},{"key":"B5","unstructured":"Prusiner SB. 2003. 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