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We also discuss the neurologic phenotypes that arise from mutations in neurotransmitter receptors (lurcher mice) and ion channels (weaver, leaner, and tottering mice), drawing parallels between ischemic cell death and the neurodegeneration that occurs in the lurcher mouse. Finally, we discuss common mechanisms of cell death and lessons learned from these mouse models that might have broader relevance to other neurologic disorders. <\/jats:p>","DOI":"10.1146\/annurev.physiol.62.1.779","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:46:15Z","timestamp":1027770375000},"page":"779-802","source":"Crossref","is-referenced-by-count":68,"title":["Insights from Mouse Models into the Molecular Basis of Neurodegeneration"],"prefix":"10.1146","volume":"62","author":[{"given":"N.","family":"Heintz","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, The Rockefeller University, New York, New York, 10021;"},{"name":", Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, 77030;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Y.","family":"Zoghbi","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, The Rockefeller University, New York, New York, 10021;"},{"name":", Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, 77030;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"crossref","unstructured":"Fu Y-H, Kuhl DPA, Pizutti A, Pieretti M, Sutcliffe JS, et al. 1991. Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox.Cell67:1047\u201358","DOI":"10.1016\/0092-8674(91)90283-5"},{"key":"b2","doi-asserted-by":"crossref","unstructured":"La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck H. 1991. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy.Nature352:77\u201379","DOI":"10.1038\/352077a0"},{"key":"b3","unstructured":"Zoghbi HY, Ballabio A. 1995. Spinocerebellar ataxia Type 1. 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