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Plasma membrane Cl<jats:sup>\u2212<\/jats:sup> channels are known to play an integral role in transcellular Cl<jats:sup>\u2212<\/jats:sup> transport in both the thin and thick ascending limbs. This review focuses on the functional characteristics and molecular identities of these Cl<jats:sup>\u2212<\/jats:sup> channels, as well as the role of these channels in the pathophysiology of disease. <\/jats:p>","DOI":"10.1146\/annurev.physiol.63.1.631","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T11:40:39Z","timestamp":1027770039000},"page":"631-645","source":"Crossref","is-referenced-by-count":28,"title":["Chloride Channels in the Loop of Henle"],"prefix":"10.1146","volume":"63","author":[{"given":"W Brian","family":"Reeves","sequence":"first","affiliation":[{"name":"Division of Nephrology, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas, 72205;"},{"name":"Department of Internal Medicine, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas, 72205;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J","family":"Winters","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas, 72205;"},{"name":"Department of Internal Medicine, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas, 72205;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E","family":"Andreoli","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas, 72205;"},{"name":"Department of Internal Medicine, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas, 72205;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105710"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1964.206.4.687"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1967.212.6.1327"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1972.97"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1972.75"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1968.215.1.236"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1967.212.2.357"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1977.232.3.F201"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107572"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108556"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1982.243.2.F167"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1979.237.2.F114"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113691"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1988.254.2.F232"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1987.253.6.F1206"},{"key":"b16","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1016\/S0021-9258(18)53545-6","volume":"268","author":"Uchida S","year":"1993","journal-title":"J. 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