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Herein, we review the current knowledge pertaining to the structural and functional features of ubiquitin-binding proteins and the mechanisms by which they recognize various types of ubiquitin topologies. The combinatorial use of diverse ubiquitin-binding domains (UBDs) in full-length proteins, selective recognition of chains with distinct linkages and length, and posttranslational modifications of ubiquitin receptors or multivalent interactions within protein complexes illustrate a few mechanisms by which a circuitry of signaling networks can be rewired by ubiquitin-binding proteins to control cellular functions in vivo. <\/jats:p>","DOI":"10.1146\/annurev-biochem-051810-094654","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T19:57:27Z","timestamp":1337716647000},"page":"291-322","source":"Crossref","is-referenced-by-count":697,"title":["Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions"],"prefix":"10.1146","volume":"81","author":[{"given":"Koraljka","family":"Husnjak","sequence":"first","affiliation":[{"name":"Institute of Biochemistry II, School of 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