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Although the biological significance of noncoding RNA editing remains largely unknown, several possibilities, including its role in the control of endogenous short interfering RNAs (esiRNAs), have been proposed. Furthermore, recent studies have revealed that the biogenesis and functions of certain microRNAs (miRNAs) are regulated by the editing of their precursors. Here, I review the recent findings that indicate new functions for A\u2192I editing in the regulation of noncoding RNAs and for interactions between RNA editing and RNA interference mechanisms. <\/jats:p>","DOI":"10.1146\/annurev-biochem-060208-105251","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T23:40:17Z","timestamp":1276126817000},"page":"321-349","source":"Crossref","is-referenced-by-count":1166,"title":["Functions and Regulation of RNA Editing by ADAR Deaminases"],"prefix":"10.1146","volume":"79","author":[{"given":"Kazuko","family":"Nishikura","sequence":"first","affiliation":[{"name":"Department of Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 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