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The effect of perturbing cilia length and number is discussed and compared in mouse and zebrafish. Whereas understanding of this process has advanced significantly over the past two decades, there is still no consensus on how flow is converted to asymmetric gene expression, with most research focusing on resolving mechanical versus morphogen sensing. The underlying process may be more subtle, probably involving a combination of these effects, with fluid mechanics playing a central role. <\/jats:p>","DOI":"10.1146\/annurev-fluid-010518-040231","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T21:27:48Z","timestamp":1534368468000},"page":"105-128","source":"Crossref","is-referenced-by-count":44,"title":["Symmetry-Breaking Cilia-Driven Flow in Embryogenesis"],"prefix":"10.1146","volume":"51","author":[{"given":"David J.","family":"Smith","sequence":"first","affiliation":[{"name":"School of Mathematics, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"},{"name":"Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom"}]},{"given":"Thomas D.","family":"Montenegro-Johnson","sequence":"additional","affiliation":[{"name":"School of Mathematics, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom;"}]},{"given":"Susana S.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Chronic Diseases Research Centre (CEDOC), NOVA Medical School Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal"}]}],"member":"22","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084576"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2008.01.032"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-004-1203-y"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-003-1072-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1017\/S0305004100049902"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02353701"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1242\/dev.100560"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20046"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010715)101:4<339::AID-AJMG1442>3.0.CO;2-P"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.063743"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2006.0155"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402001101"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.05.027"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1137\/S106482750038146X"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1063\/1.1830486"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nature17426"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.109.038101"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01663"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25078"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1242\/dev.073593"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24355"},{"key":"B22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1242\/jeb.32.4.802","volume":"32","author":"Gray J","year":"1955","journal-title":"J. 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