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Here, we describe the interactions of the different branches of the peripheral nervous system with immune cells in various organs, including the skin, intestine, lung, and adipose tissue. We highlight how neuroimmune crosstalk orchestrates physiological processes such as host defense, tissue repair, metabolism, and thermogenesis. Unraveling these intricate relationships is invaluable to explore the therapeutic potential of neuroimmune interactions. <\/jats:p>","DOI":"10.1146\/annurev-neuro-111020-105359","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T18:45:09Z","timestamp":1648838709000},"page":"339-360","source":"Crossref","is-referenced-by-count":130,"title":["Neuroimmune Interactions in Peripheral Organs"],"prefix":"10.1146","volume":"45","author":[{"given":"Roel G.J.","family":"Klein Wolterink","sequence":"first","affiliation":[{"name":"Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal;"}]},{"given":"Glendon S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA;"}]},{"given":"Isaac M.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, USA;"}]},{"given":"Henrique","family":"Veiga-Fernandes","sequence":"additional","affiliation":[{"name":"Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal;"}]}],"member":"22","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2733092.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(87)90055-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature13383"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03894.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4501"},{"issue":"2","key":"B6","first-page":"208","volume":"280","author":"Barnes PJ.","year":"1986","journal-title":"Arch. 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