{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:33:59Z","timestamp":1789522439178,"version":"build-2803163510"},"reference-count":150,"publisher":"Annual Reviews","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annu. Rev. Pathol. Mech. Dis."],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:p>Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.<\/jats:p>","DOI":"10.1146\/annurev-pathol-121808-102144","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T18:23:41Z","timestamp":1263579821000},"page":"99-118","source":"Crossref","is-referenced-by-count":4825,"title":["The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression"],"prefix":"10.1146","volume":"5","author":[{"given":"Jean-Philippe","family":"Copp\u00e9","sequence":"first","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Desprez","sequence":"additional","affiliation":[{"name":"Buck Institute for Age Research, Novato, California 94945"},{"name":"California Pacific Medical Center, Cancer Research Institute, San Francisco, California 94107;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Krtolica","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Campisi","sequence":"additional","affiliation":[{"name":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720"},{"name":"Buck Institute for Age Research, Novato, California 94945"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1415"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.05.024"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1782"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nm0905-920"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nature03841"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature03918"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/436642a"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature03890"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.10.003"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nature05541"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nature05529"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.211053698"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0062"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.038"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.039"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.003"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060301"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2233"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2009.22"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420663"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.10.013"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1044"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.003"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.031"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.006"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.028"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.001"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4006"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1884"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.030"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000177474.06749.98"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.626606"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2560"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80420-5"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5462.2486"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4632"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206187"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206594"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2627983100"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2004.00105.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.07.002"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.108"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208692"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1716"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50097"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000022161.42655.98"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1049fje"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1247\/csf.28.495"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200500746"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200373200"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012602599"},{"key":"B54","first-page":"6255","volume":"62","author":"Untergasser G","year":"2002","journal-title":"Cancer Res."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207834"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1593\/neo.05250"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi357"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1772"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1909"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.4.1559"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1159\/000163946"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218499"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4683"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4341"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)01941-X"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10204"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1177\/1358836X0501000110"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2005.00173.x"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(96)01814-3"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00080-2"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7783"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.032"},{"key":"B73","doi-asserted-by":"crossref","first-page":"10789","DOI":"10.1016\/S0021-9258(18)82054-3","volume":"268","author":"Huang NN","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(89)90372-8"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90286-H"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1996.0019"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01635"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3452"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00049-0"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1160.h81602001160_1160_1167"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03760.x"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/nrm977"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1232"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(95)02013-6"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041650324"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199801)174:1<90::AID-JCP10>3.0.CO;2-S"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613457"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1448"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1994.1181"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1103"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2153"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.7936"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.12.1731"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.9.2180"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(03)00163-5"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/35041687"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/nature05985"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-007-0115-7"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1395.027"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603636"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00313.x"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg417"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00401-X"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.1.389-401.2003"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00256-4"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.7.2842-2852.2004"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nature05092"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/nature05159"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/nature05091"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/10480"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/415045a"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1162404"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3791"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0703"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.050"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00538-0"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2464"},{"key":"B118","first-page":"1254","volume":"60","author":"Barcellos-Hoff MH","year":"2000","journal-title":"Cancer Res."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1702"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6538"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00308-2"},{"key":"B122","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.72.1.9","volume":"72","author":"Dhawan P","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"B123","first-page":"1115","volume":"6","author":"Balentien E","year":"1991","journal-title":"Oncogene"},{"key":"B124","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.4049\/jimmunol.151.5.2667","volume":"151","author":"Schadendorf D","year":"1993","journal-title":"J. Immunol."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4039"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7571"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603307200"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.028"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29906"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1261"},{"key":"B131","first-page":"2207","volume":"61","author":"Camphausen K","year":"2001","journal-title":"Cancer Res."},{"key":"B132","first-page":"1223","volume":"8","author":"Qian LW","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.006"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30070-X"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2388"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2003.10.010"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1038\/nri748"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1388"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.07.006"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.8.2185"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205297"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/nrc822"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206816"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.11.6483"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10775"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.01.003"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/nm0697-632"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5449.2507"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/nrc991"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210295"}],"container-title":["Annual Review of Pathology: Mechanisms of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.annualreviews.org\/doi\/pdf\/10.1146\/annurev-pathol-121808-102144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T12:11:40Z","timestamp":1685362300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.annualreviews.org\/doi\/10.1146\/annurev-pathol-121808-102144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,1]]},"references-count":150,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1,1]]}},"alternative-id":["10.1146\/annurev-pathol-121808-102144"],"URL":"https:\/\/doi.org\/10.1146\/annurev-pathol-121808-102144","relation":{},"ISSN":["1553-4006","1553-4014"],"issn-type":[{"value":"1553-4006","type":"print"},{"value":"1553-4014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,1]]}}}