{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T08:44:56Z","timestamp":1781945096429,"version":"3.54.5"},"reference-count":154,"publisher":"Radiological Society of North America (RSNA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1148\/radiol.12110339","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T11:47:34Z","timestamp":1340279254000},"page":"6-19","source":"Crossref","is-referenced-by-count":79,"title":["New Treatments and Imaging Strategies in Degenerative Disease of the Intervertebral Disks"],"prefix":"10.1148","volume":"264","author":[{"given":"Jeffrey C.","family":"Lotz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Haughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Boden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S.","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Freemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd","family":"Berven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip K.","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Tanenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Ranganathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abass","family":"Alavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1577","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110973"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.23.092101.134534"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431008"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-3-201102010-00008"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.12.003"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-010-1502-y"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh599"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199602150-00003"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199105000-00006"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1136\/aim.22.4.178"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000146499.97948.52"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2010.07.016"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709885200"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199801010-00001"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.3109\/03009737909179143"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2007.08.001"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken396"},{"issue":"6","key":"r18","volume":"5","author":"Anderson DG","year":"2005","journal-title":"Spine J"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000146101.53784.b1"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01341"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00019"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20874"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X78B6.1287"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.79B1.6814"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000215027.87102.7c"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000201324.45537.46"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.43.2.302"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000231761.73859.2c"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2006.07.003"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(86)90131-4"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198909000-00012"},{"issue":"3","key":"r32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2106\/00004623-199072030-00013","volume":"72","author":"Boden SD","year":"1990","journal-title":"J Bone Joint Surg Am"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-9-11"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5.647"},{"issue":"4","key":"r35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.36076\/ppj.2001\/4\/308","volume":"4","author":"Manchikanti L","year":"2001","journal-title":"Pain Physician"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/16.1.3"},{"issue":"2","key":"r37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0030-5898(20)31644-8","volume":"22","author":"Kuslich SD","year":"1991","journal-title":"Orthop Clin North Am"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200002150-00016"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200004010-00014"},{"key":"r40","doi-asserted-by":"publisher","DOI":"10.1080\/03008200802147951"},{"key":"r41","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199705150-00003"},{"key":"r42","doi-asserted-by":"publisher","DOI":"10.1186\/ar2487"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.1002\/art.10585"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000217669.04903.61"},{"key":"r45","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02135-1"},{"key":"r46","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199710150-00005"},{"key":"r47","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31815b9850"},{"key":"r48","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198607000-00028"},{"key":"r49","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199503150-00006"},{"key":"r50","volume-title":"Low back pain; a scientific and clinical overview","author":"Cavanaugh JM","year":"1996"},{"key":"r51","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199812010-00008"},{"key":"r52","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200104150-00007"},{"key":"r53","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.03.029"},{"key":"r54","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.1.2136783"},{"issue":"4","key":"r55","doi-asserted-by":"crossref","first-page":"513","DOI":"10.36076\/ppj.2008\/11\/513","volume":"11","author":"Wolfer LR","year":"2008","journal-title":"Pain Physician"},{"key":"r56","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-9430(01)00051-1"},{"key":"r57","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181ab5432"},{"key":"r58","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199801010-00024"},{"key":"r59","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2451051706"},{"key":"r60","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181a18263"},{"key":"r61","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0787-6"},{"key":"r62","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-007-0530-8"},{"key":"r63","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200006150-00006"},{"key":"r64","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200109010-00011"},{"key":"r65","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2259"},{"key":"r66","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200205010-00006"},{"key":"r67","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000217708.54880.51"},{"key":"r68","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200104150-00010"},{"key":"r69","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199806010-00016"},{"issue":"2","key":"r70","first-page":"163","volume":"30","author":"Cohen SP","year":"2005","journal-title":"Reg Anesth Pain Med"},{"key":"r71","doi-asserted-by":"publisher","DOI":"10.1097\/01.ajp.0000208244.33498.05"},{"key":"r72","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100100410"},{"key":"r73","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199106000-00006"},{"key":"r74","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318195dd44"},{"key":"r75","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200001)43:1<34::AID-MRM5>3.0.CO;2-7"},{"key":"r76","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.188.2.8327677"},{"key":"r77","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100120407"},{"key":"r78","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-58-692-705"},{"key":"r79","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2080"},{"key":"r80","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2142"},{"key":"r81","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.2001.420610.x"},{"key":"r82","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(94)92452-X"},{"key":"r83","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200110010-00017"},{"key":"r84","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400616"},{"key":"r85","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100150121"},{"key":"r86","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20609"},{"key":"r87","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01051"},{"key":"r88","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1102"},{"key":"r89","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(03)80666-9"},{"key":"r90","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.00667"},{"key":"r91","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-006-0083-2"},{"key":"r92","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31820287bf"},{"key":"r93","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181b4df92"},{"issue":"6","key":"r95","first-page":"1307","volume":"16","author":"Ibrahim MA","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"r96","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181e9a156"},{"key":"r97","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0645-6"},{"key":"r98","doi-asserted-by":"publisher","DOI":"10.1002\/path.1050"},{"key":"r99","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090111"},{"key":"r100","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(01)00332-3"},{"key":"r101","doi-asserted-by":"publisher","DOI":"10.1007\/BF02146615"},{"key":"r102","doi-asserted-by":"publisher","DOI":"10.3109\/17453676908989482"},{"key":"r103","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31816201c3"},{"key":"r104","author":"Hu S","year":"2010","journal-title":"Presented at the 2010 Annual Meeting of the Orthopaedic Research Society"},{"key":"r105","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2004.07.005"},{"key":"r106","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.037200"},{"key":"r107","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.73562"},{"key":"r108","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2007.01.005"},{"key":"r109","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000146048.14946.af"},{"key":"r110","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200009010-00002"},{"key":"r111","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3647"},{"key":"r112","doi-asserted-by":"publisher","DOI":"10.1142\/S0218957700000185"},{"key":"r113","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199103000-00001"},{"key":"r114","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000101445.46487.16"},{"key":"r115","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000083204.44190.34"},{"key":"r116","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00037-8"},{"key":"r117","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000148002.68656.4d"},{"key":"r118","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000130031.64343.59"},{"key":"r119","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000206358.66412.7b"},{"key":"r120","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2006.04.014"},{"key":"r121","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3180574d26"},{"key":"r122","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000248428.22823.86"},{"key":"r123","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000232792.66632.d8"},{"key":"r124","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198811000-00014"},{"key":"r125","doi-asserted-by":"publisher","DOI":"10.1186\/ar1732"},{"key":"r126","doi-asserted-by":"publisher","DOI":"10.1111\/j.0959-9673.2006.00449.x"},{"key":"r127","doi-asserted-by":"publisher","DOI":"10.1186\/ar2282"},{"key":"r128","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1397.069"},{"key":"r129","doi-asserted-by":"publisher","DOI":"10.1186\/ar2275"},{"key":"r130","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000149186.63457.20"},{"key":"r131","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2008.04.019"},{"key":"r132","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000085303.67942.94"},{"key":"r133","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01328"},{"issue":"7","key":"r134","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2106\/00004623-199507000-00021","volume":"77","author":"Evans CH","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"r135","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00020-5"},{"key":"r136","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200806000-00003"},{"key":"r137","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302200"},{"key":"r138","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199811150-00016"},{"key":"r139","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199912010-00002"},{"key":"r140","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000146103.94600.85"},{"key":"r141","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31816b4619"},{"key":"r142","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.07.394"},{"key":"r143","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000131416.90906.20"},{"key":"r144","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.09.011"},{"key":"r145","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000148048.15348.9b"},{"key":"r146","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.06.038"},{"key":"r147","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200108000-00015"},{"key":"r148","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000187880.39298.f0"},{"key":"r149","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181a54157"},{"key":"r150","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000175174.50235.ba"},{"key":"r151","unstructured":"National Center for Health Statistics. Health, United States, 2006: With chartbook on trends in the health of Americans. Hyattsville, Md: National Center for Health Statistics, 2006."},{"key":"r152","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.01273"},{"key":"r153","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7141.1356"},{"key":"r154","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2296-8-40"},{"key":"r155","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2753.2001.00284.x"}],"container-title":["Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsna.org\/doi\/pdf\/10.1148\/radiol.12110339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T05:42:58Z","timestamp":1642570978000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsna.org\/doi\/10.1148\/radiol.12110339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":154,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1148\/radiol.12110339"],"URL":"https:\/\/doi.org\/10.1148\/radiol.12110339","relation":{},"ISSN":["0033-8419","1527-1315"],"issn-type":[{"value":"0033-8419","type":"print"},{"value":"1527-1315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}