{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:17:45Z","timestamp":1791155865242,"version":"4.1.0"},"reference-count":43,"publisher":"Radiological Society of North America (RSNA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1148\/radiol.2503080811","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T02:51:04Z","timestamp":1232592664000},"page":"878-886","source":"Crossref","is-referenced-by-count":87,"title":["Existence of the Diffusion-Perfusion Mismatch within 24 Hours after Onset of Acute Stroke: Dependence on Proximal Arterial Occlusion"],"prefix":"10.1148","volume":"250","author":[{"given":"William A.","family":"Copen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Rezai Gharai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Barak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee H.","family":"Schwamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ona","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahmir","family":"Kamalian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Gilberto","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1577","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.9.1151"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy?an analysis of patient eligibility. Neurology2001;56:1015\u20131020.","DOI":"10.1212\/WNL.56.8.1015"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152041.20486.2F"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-3-199808010-00005"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490375"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(99)70411-7"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000109767.11426.17"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130023023"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08020-9"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2019"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000155737.43566.ad"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000149938.08731.2c"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000217403.66996.6d"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.2.r99fe06519"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.8.1591"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.10.2043"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320113"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Wolpert SM, Bruckmann H, Greenlee R, Wechsler L, Pessin MS, del Zoppo GJ. Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator: the rt-PA Acute Stroke Study Group.AJNR Am J Neuroradiol1993;14:3\u201313.","DOI":"10.1007\/978-3-642-78061-5_26"},{"key":"R20","unstructured":"Jansen O, von Kummer R, Forsting M, Hacke W, Sartor K. Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation.AJNR Am J Neuroradiol1995;16:1977\u20131986."},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251788.03914.00"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000257304.21967.ba"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250341.38014.d2"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10308"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360510"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.4.931"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(02)00629-X"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0831"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10020"},{"key":"R30","unstructured":"Hossmann KA. Periinfarct depolarizations.Cerebrovasc Brain Metab Rev1996;8:195\u2013208."},{"key":"R31","doi-asserted-by":"crossref","unstructured":"Busch E, Gyngell ML, Eis M, Hoehn-Berlage M, Hossmann KA. Potassium-induced cortical spreading depressions during focal cerebral ischemia in rats: contribution to lesion growth assessed by diffusion-weighted NMR and biochemical imaging.J Cereb Blood Flow Metab1996;16:1090\u20131099.","DOI":"10.1097\/00004647-199611000-00002"},{"key":"R32","doi-asserted-by":"crossref","unstructured":"Barone FC, Feuerstein GZ. Inflammatory mediators and stroke: new opportunities for novel therapeutics.J Cereb Blood Flow Metab1999;19:819\u2013834.","DOI":"10.1097\/00004647-199908000-00001"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00261.x"},{"key":"R34","doi-asserted-by":"crossref","unstructured":"Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain.J Cereb Blood Flow Metab2001;21:2\u201314.","DOI":"10.1097\/00004647-200101000-00002"},{"key":"R35","doi-asserted-by":"crossref","unstructured":"Hartings JA, Rolli ML, Lu XC, Tortella FC. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection.J Neurosci2003;23:11602\u201311610.","DOI":"10.1523\/JNEUROSCI.23-37-11602.2003"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.6"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1161\/hs0302.104110"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15692-4"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.12.2598"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.11.2552"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000020363.23725.67"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000121641.77121.98"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000227358.37094.46"}],"container-title":["Radiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsna.org\/doi\/pdf\/10.1148\/radiol.2503080811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:55:28Z","timestamp":1684864528000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsna.org\/doi\/10.1148\/radiol.2503080811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1148\/radiol.2503080811"],"URL":"https:\/\/doi.org\/10.1148\/radiol.2503080811","relation":{},"ISSN":["0033-8419","1527-1315"],"issn-type":[{"value":"0033-8419","type":"print"},{"value":"1527-1315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}