{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:39:44Z","timestamp":1791221984838,"version":"4.1.0"},"reference-count":50,"publisher":"Radiological Society of North America (RSNA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RadioGraphics"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>Mastocytosis is a rare c-KIT\u2013driven clonal disorder for which radiologic evaluation is essential in the early detection of hallmark features, including hepatosplenomegaly, lymphadenopathy, and skeletal abnormalities, which facilitates diagnosis, differentiation from mimics, and disease monitoring.<\/jats:p>","DOI":"10.1148\/rg.250075","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:50:18Z","timestamp":1766512218000},"source":"Crossref","is-referenced-by-count":3,"title":["Mastocytosis: Imaging Spectrum and Diagnostic                     Insights"],"prefix":"10.1148","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-4528","authenticated-orcid":false,"given":"Rachita","family":"Khot","sequence":"first","affiliation":[{"name":"Department of Radiology and Medical Imaging, University                     of Virginia, Charlottesville, Va"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9866-1864","authenticated-orcid":false,"given":"Mahmoud","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"},{"name":"Department of Diagnostic and Interventional Radiology,                     Faculty of Medicine, Suez Canal University, Ismailia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6660-2178","authenticated-orcid":false,"given":"James M.","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2184-3975","authenticated-orcid":false,"given":"Mamie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4736-656X","authenticated-orcid":false,"given":"Ahmed","family":"Elbanna","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Rupe","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar Samir","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Yale New Haven Health,                     Storrs, Conn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-7369","authenticated-orcid":false,"given":"Albert R.","family":"Klekers","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2540-9246","authenticated-orcid":false,"given":"Ayman","family":"Gaballah","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-0717","authenticated-orcid":false,"given":"Khaled M.","family":"Elsayes","sequence":"additional","affiliation":[{"name":"Department of Abdominal Imaging, The University of Texas                     MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1577","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.04.041"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2021.056"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-031521-042618"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15235626"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0956-z"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8619-2"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4213"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2013.09.001"},{"key":"r10","unstructured":"WHO Classification of Tumours Editorial                         Board. WHO Classification of                         Tumours: Haematolymphoid Tumours. 5th                         ed. WHO; 2024. https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Who-Classification-Of-Tumours\/Haematolymphoid-Tumours-2024.                         Accessed February 23, 2025."},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14020161"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071474"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2325"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13567"},{"key":"r15","doi-asserted-by":"crossref","unstructured":"Pardanani A. Systemic                         mastocytosis in adults: 2023 update on diagnosis, risk stratification and                         management. Am J                         Hematol 2023;98(7):1097\u20131116.","DOI":"10.1002\/ajh.26962"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11812"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01014-w"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100693"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-012-1374-9"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02780.x"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18537-6"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1232"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03826-4"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i29.3767"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2009.02.013"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1500-9"},{"key":"r27","doi-asserted-by":"crossref","unstructured":"Seppelt D. Simple                         diameter measurement as predictor of liver volume and liver parenchymal                         disease. Sci                         Rep 2022;12: article                         number 1257","DOI":"10.1038\/s41598-022-04825-8"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2017.30"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.65.764.394"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100312"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.2.9015059"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205102"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.137"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15.32.x"},{"key":"r35","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12387"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1097\/00005382-200401000-00011"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26716"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.05.007"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.01.006"},{"key":"r40","doi-asserted-by":"crossref","unstructured":"Akin C. Mast                         cell activation syndromes. J Allergy Clin                         Immunol 2017;140(2):349\u2013355.","DOI":"10.1016\/j.jaci.2017.06.007"},{"key":"r41","doi-asserted-by":"crossref","unstructured":"Metz DC. Diagnosis                         of the Zollinger\u2013Ellison                         Syndrome. Clin Gastroenterol                         Hepatol 2012;10(2):126\u2013130.","DOI":"10.1016\/j.cgh.2011.07.012"},{"key":"r42","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e318211496c"},{"key":"r43","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ebaffd"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70410-2"},{"key":"r45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1806651"},{"key":"r46","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00852-3"},{"key":"r47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1808012"},{"key":"r48","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404955"},{"key":"r49","doi-asserted-by":"crossref","unstructured":"Radia DH. How                         I diagnose and treat systemic mastocytosis with an associated hematologic                         neoplasm. Blood 2025;145(16):1747\u20131757.","DOI":"10.1182\/blood.2023022416"},{"key":"r50","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00216-3"}],"container-title":["RadioGraphics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsna.org\/doi\/pdf\/10.1148\/rg.250075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:50:20Z","timestamp":1766512220000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsna.org\/doi\/10.1148\/rg.250075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1148\/rg.250075"],"URL":"https:\/\/doi.org\/10.1148\/rg.250075","relation":{},"ISSN":["0271-5333","1527-1323"],"issn-type":[{"value":"0271-5333","type":"print"},{"value":"1527-1323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"e250075"}}