{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:39:53Z","timestamp":1792679993025,"version":"4.5.0"},"reference-count":36,"publisher":"Radiological Society of North America (RSNA)","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH 2R01HL126771"],"award-info":[{"award-number":["NIH 2R01HL126771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL151588"],"award-info":[{"award-number":["R01HL151588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL143011"],"award-info":[{"award-number":["R01HL143011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiology: Cardiothoracic Imaging"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Hyperpolarized xenon 129 MRI revealed gas-exchange abnormalities in participants with cystic fibrosis compared with control participants; these abnormalities were not correlated with spirometry but persisted despite cystic fibrosis transmembrane conductance regulator modulator therapy.<\/jats:p>","DOI":"10.1148\/ryct.250295","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:51:21Z","timestamp":1792677081000},"source":"Crossref","is-referenced-by-count":0,"title":["Hyperpolarized Xenon 129 MRI to Evaluate Regional Gas-Exchange                     Abnormalities in Cystic Fibrosis Lung Disease"],"prefix":"10.1148","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-8224","authenticated-orcid":false,"given":"Stephanie A.","family":"Soderlund","sequence":"first","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Department of Biomedical Engineering, University of                     Cincinnati, Cincinnati, Ohio"},{"name":"University of Cincinnati, College of Medicine,                     Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-9428","authenticated-orcid":false,"given":"Bilal I.","family":"Masokano","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Department of Biomedical Engineering, University of                     Cincinnati, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-9622","authenticated-orcid":false,"given":"Matthew M.","family":"Willmering","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Division of Pulmonary Medicine, Cincinnati                     Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati                     Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-7032","authenticated-orcid":false,"given":"Abdullah S.","family":"Bdaiwi","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Division of Pulmonary Medicine, Cincinnati                     Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-2345","authenticated-orcid":false,"given":"Riaz","family":"Hussain","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Division of Pulmonary Medicine, Cincinnati                     Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-2161","authenticated-orcid":false,"given":"Elizabeth L.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Cincinnati                     Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati                     Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-6401","authenticated-orcid":false,"given":"Laura L.","family":"Walkup","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Department of Biomedical Engineering, University of                     Cincinnati, Cincinnati, Ohio"},{"name":"Division of Pulmonary Medicine, Cincinnati                     Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati                     Medical Center, Cincinnati, Ohio"},{"name":"Imaging Research Center, Department of Radiology,                     University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-9061","authenticated-orcid":false,"given":"Zackary I.","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Cincinnati                     Children\u2019s Hospital Medical Center, 3333 Burnet Ave, MLC-2021,                     Cincinnati, OH 45229"},{"name":"Department of Biomedical Engineering, University of                     Cincinnati, Cincinnati, Ohio"},{"name":"Division of Pulmonary Medicine, Cincinnati                     Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Department of Pediatrics, University of Cincinnati                     Medical Center, Cincinnati, Ohio"},{"name":"Imaging Research Center, Department of Radiology,                     University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1577","reference":[{"key":"r1","volume-title":"Cystic Fibrosis Foundation Patient Registry","author":"Cystic Fibrosis Foundation","year":"2023"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.02.004"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01918-2015"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202308-1317OC"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073142"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128062"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02620-0"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-020-04706-0"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00748-2019"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2016.07.014"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.07.008"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020192804"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2024.07.002"},{"key":"r15","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28609"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211433"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.09.064"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00289-2020"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28136"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30028"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27800"},{"key":"r22","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28737"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29501"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.30586"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.02.045"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4639"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.01.017"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29627"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.8961"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-74"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2010.09.006"},{"key":"r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2017.08.002"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-30"},{"key":"r34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202305-0818OC"},{"key":"r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2022.06.007"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.05.001"}],"container-title":["Radiology: Cardiothoracic Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsna.org\/doi\/pdf\/10.1148\/ryct.250295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:51:22Z","timestamp":1792677082000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsna.org\/doi\/10.1148\/ryct.250295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1148\/ryct.250295"],"URL":"https:\/\/doi.org\/10.1148\/ryct.250295","relation":{},"ISSN":["2638-6135"],"issn-type":[{"value":"2638-6135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"e250295"}}