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DMO was passively distributed between bile and plasma. The data indicate that a bicarbonate transport mechanism is responsible for production of up to 50% of the BSIF. Another weak acid, N-5[5-(2-methoxyethoxy)-2-pyrimidinyl]sulfamoylbenzene (glymidine), was rapidly excreted into bile and increased bile flow by over 2.0 microliter\/g.min. Glymidine is probably excreted by an independent organic anion transport mechanism, and any effect on the bicarbonate transport mechanism is obscured. Canaliculus-enriched hepatocyte membrane fractions contained no HCO3-stimulated ATPase activity. Either this enzyme is unimportant in hepatocyte bicarbonate transport or transport occurs across membranes other than the bile canalicular membrane.<\/jats:p>","DOI":"10.1152\/ajpendo.1978.235.2.e158","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T05:56:27Z","timestamp":1514181387000},"page":"E158","source":"Crossref","is-referenced-by-count":3,"title":["Importance of bicarbonate in bile salt independent fraction of bile flow."],"prefix":"10.1152","volume":"235","author":[{"given":"W G","family":"Hardison","sequence":"first","affiliation":[]},{"given":"C A","family":"Wood","sequence":"additional","affiliation":[]}],"member":"24","reference":[{"key":"p_2","first-page":"59","volume":"401","author":"BOYER J. L.","year":"1975","journal-title":"Acta"},{"key":"p_3","first-page":"257","volume":"73","author":"CAREL H","year":"1977","journal-title":"J. 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