{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:50:32Z","timestamp":1775040632468,"version":"3.50.1"},"reference-count":12,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[1993,12,1]]},"abstract":"<jats:p> Six male subjects received either a saline (control) or Intralipid infusion during 30 min rest and 15 min cycling at 85% maximal O2 uptake (VO2max) to examine the regulation of fat-carbohydrate interaction (glucose-fatty acid cycle) in skeletal muscle. Muscle biopsies were sampled immediately before and at 3 and 15 min of exercise in both trials. A muscle biopsy was also taken at -30 min rest in the Intralipid trial. Intralipid infusion significantly elevated plasma free fatty acids above control during rest (0.21 +\/- 0.04 to 0.94 +\/- 0.09 mM) and exercise (5 min: 1.27 +\/- 0.15 mM; 15 min: 1.42 +\/- 0.13 mM). Muscle glycogen degradation was significantly lower in the Intralipid trial (109.7 +\/- 29.3 vs. 194.7 +\/- 32.1 mmol\/kg dry muscle). Muscle lactate accumulation after 15 min was similar in both trials (control, 60.7 +\/- 12.2 and Intralipid, 60.9 +\/- 12.4 mmol\/kg dry muscle). Muscle citrate increased at rest during Intralipid (0.32 +\/- 0.06 to 0.58 +\/- 0.06 mmol\/kg dry muscle) but was not different between trials at 3 min (control, 0.73 +\/- 0.07 and Intralipid, 0.68 +\/- 0.06 mmol\/kg dry muscle) and 15 min of cycling. Resting acetyl-CoA was unaffected by Intralipid and increased similarly in both trials at 3 min of cycling (control, 59.0 +\/- 10.3 and Intralipid, 50.7 +\/- 13.6 mumol\/kg dry muscle) and remained unchanged at 15 min. Pyruvate dehydrogenase activity increased five- to sevenfold during exercise and was similar in both trials (15 min: control, 2.42 +\/- 0.30 and Intralipid, 2.79 +\/- 0.41 mmol.min-1 x kg wet wt-1).(ABSTRACT TRUNCATED AT 250 WORDS) <\/jats:p>","DOI":"10.1152\/ajpendo.1993.265.6.e852","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:39:22Z","timestamp":1513903162000},"page":"E852-E859","source":"Crossref","is-referenced-by-count":48,"title":["Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling"],"prefix":"10.1152","volume":"265","author":[{"given":"D. J.","family":"Dyck","sequence":"first","affiliation":[{"name":"School of Human Biology, University of Guelph, Ontario, Canada."}]},{"given":"C. T.","family":"Putman","sequence":"additional","affiliation":[{"name":"School of Human Biology, University of Guelph, Ontario, Canada."}]},{"given":"G. 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