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Exercise did not change plasma or gastrocnemius IGF-I concentrations in nondiabetic rats. However, plasma and muscle IGF-I concentrations were higher in IgG-treated diabetic rats that exercised compared with respective sedentary groups ( P &lt; 0.05). Passively immunized diabetic rats did not exhibit the same exercise-induced increase in IGF-I concentrations. In nondiabetic rats, protein synthesis rates were higher after exercise in both control and immunized groups. In diabetic rats, exercise increased protein synthesis in the IgG-treated animals but not in those treated with IGF-I antibody. There was also a significant positive correlation between both plasma and gastrocnemius IGF-I concentrations and rates of protein synthesis in diabetic ( P &lt; 0.01), but not nondiabetic, rats. These results suggest that IGF-I is compensatory for insulin in hypoinsulinemic rats by facilitating an anabolic response after acute resistance exercise.<\/jats:p>","DOI":"10.1152\/ajpendo.2001.280.6.e877","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T17:59:46Z","timestamp":1513965586000},"page":"E877-E885","source":"Crossref","is-referenced-by-count":15,"title":["Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise"],"prefix":"10.1152","volume":"280","author":[{"given":"Mark J.","family":"Fedele","sequence":"first","affiliation":[{"name":"Noll Physiological Research Center, Pennsylvania State University, University Park 16802; and Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Lang","sequence":"additional","affiliation":[{"name":"Noll Physiological Research Center, Pennsylvania State University, University Park 16802; and Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Farrell","sequence":"additional","affiliation":[{"name":"Noll Physiological Research Center, Pennsylvania State University, University Park 16802; and Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.6.2509"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.5.1716"},{"key":"B4","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1016\/S0021-9258(17)35621-1","volume":"261","author":"Ashford AJ","year":"1986","journal-title":"J Biol Chem"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.6.E967"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.18.6898"},{"key":"B7","first-page":"2282","volume":"80","author":"Bereket A","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"B8","first-page":"1312","volume":"80","author":"Bereket A","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb26688.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(93)80207-K"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/47.2.212"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.4.7511091"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.4.1563"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.3.1075"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.6.2291"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.4.E721"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.1.102"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1980.239.1.E88"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.4.1100"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.2.E313"},{"key":"B21","first-page":"21","volume":"20","author":"Foglia VA.","year":"1944","journal-title":"Rev. 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