{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:13:41Z","timestamp":1769206421917,"version":"3.49.0"},"reference-count":32,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p> Structural remodeling of myocardium after infarction plays a critical role in functional adaptation. Diffusion tensor magnetic resonance imaging (DTMRI) provides a means for rapid and nondestructive characterization of the three-dimensional fiber architecture of cardiac tissues. In this study, microscopic structural changes caused by MI were evaluated in Fischer 344 rats 4 wk after infarct surgery. DTMRI studies were performed on 15 excised, formalin-fixed rat hearts of both infarct (left anterior descending coronary artery occlusion, n = 8) and control (sham, n = 7) rats. Infarct myocardium exhibited increased water diffusivity (41% increase in trace values) and decreased diffusion anisotropy (37% decrease in relative anisotropy index). The reduced diffusion anisotropy correlated negatively with microscopic fiber disarray determined by histological analysis ( R = 0.81). Transmural courses of fiber orientation angles in infarct zones were similar to those of normal myocardium. However, regional angular deviation of the diffusion tensor increased significantly in the infarct myocardium and correlated strongly with microscopic fiber disarray ( R = 0.86). These results suggest that DTMRI may provide a valuable tool for defining structural remodeling in diseased myocardium at the cellular and tissue level. <\/jats:p>","DOI":"10.1152\/ajpheart.00889.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:11:53Z","timestamp":1425413513000},"page":"H946-H954","source":"Crossref","is-referenced-by-count":175,"title":["Remodeling of cardiac fiber structure after infarction in rats quantified  with diffusion tensor MRI"],"prefix":"10.1152","volume":"285","author":[{"given":"Junjie","family":"Chen","sequence":"first","affiliation":[]},{"given":"Sheng-Kwei","family":"Song","sequence":"additional","affiliation":[]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Mark","family":"McLean","sequence":"additional","affiliation":[]},{"given":"J. Stacy","family":"Allen","sequence":"additional","affiliation":[]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[]},{"given":"Samuel A.","family":"Wickline","sequence":"additional","affiliation":[]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"crossref","unstructured":"Armour JA and  Randall WC. Structural basis for cardiac function. 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Wound healing after myocardial infarction. In:  Wound Healing in Cardiovascular Disease, edited by KT  Weber. Armonk, NY: Futura, 1995, p.  33\u201348."},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.259"},{"key":"REF32","unstructured":"Wu MT, Tseng  WY, Liu CP, Wedeen VJ, Reese TG, Pan HB, and Yang CF. Diffusion tensor MRI  mapping the fiber architecture of myocardium postinfarction\u2013preliminary  experience in correlation with viability map of T1201-SPECT and delay-enhanced  MRI. In: ISMRM Book of Abstracts. Conference  Proceedings of the 9th Scientific Meeting of ISMRM. 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