{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T07:13:55Z","timestamp":1715584435834},"reference-count":30,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p> The reduction in plaque volume during stent implantation is associated with the release of particulate debris and plaque-derived soluble substances. We studied the potential release of the proinflammatory cytokine TNF-\u03b1 into the coronary circulation and whether such release is related to the reduction in plaque volume and, possibly, a predictor for restenosis. In 18 male patients ( n = 24 stents) with severe stenosis in a saphenous vein aortocoronary bypass graft (SVG), we used a distal balloon occlusion-aspiration device during stent implantation. The aspirate TNF-\u03b1 levels were determined before and after stent implantation and related to the angiographic and intravascular ultrasound-assessed severity of stenosis and restenosis. We found that TNF-\u03b1 is, indeed, released into the aspirate of stented SVG (9 \u00b1 1 and 28 \u00b1 3 pg\/ml before and after stent implantation, respectively, P &lt; 0.0001) and that such release is related to the reduction in plaque volume ( r = 0.88, P &lt; 0.0001) and associated with restenosis after 5 mo ( r = 0.71, P = 0.001). The periprocedural release of plaque-derived TNF-\u03b1 possibly represents the amount and activity of the atherosclerotic process and might be a predictor for restenosis. <\/jats:p>","DOI":"10.1152\/ajpheart.01116.2006","type":"journal-article","created":{"date-parts":[[2007,1,6]],"date-time":"2007-01-06T01:33:45Z","timestamp":1168047225000},"page":"H2295-H2299","source":"Crossref","is-referenced-by-count":36,"title":["Release of TNF-\u03b1 during stent implantation into saphenous vein aortocoronary bypass grafts and its relation to plaque extrusion and restenosis"],"prefix":"10.1152","volume":"292","author":[{"given":"Dirk","family":"B\u00f6se","sequence":"first","affiliation":[]},{"given":"Kirsten","family":"Leineweber","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Konorza","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Zahn","sequence":"additional","affiliation":[]},{"given":"Martina","family":"Br\u00f6cker-Preuss","sequence":"additional","affiliation":[]},{"given":"Klaus","family":"Mann","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Haude","sequence":"additional","affiliation":[]},{"given":"Raimund","family":"Erbel","sequence":"additional","affiliation":[]},{"given":"Gerd","family":"Heusch","sequence":"additional","affiliation":[]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90291-8"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7471.912"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.24.2382"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117619"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006125205217"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1212"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.04.011"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2002.2450"},{"key":"R9","doi-asserted-by":"crossref","unstructured":"Kubica J, Kozinski M, Krzewina-Kowalska A, Zbikowska-Gotz M, Dymek G, Sukiennik A, Piasecki R, Bogdan M, Grzesk G, Chojnicki M, Dziedziczko A, Sypniewska G. Combined periprocedural evaluation of CRP and TNF-\u03b1 enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions. 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