{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:41:11Z","timestamp":1773420071111,"version":"3.50.1"},"reference-count":49,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Heart and Circulatory Physiology"],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:p>Increased sympathetic nervous system (SNS) activity plays a role in the genesis of hypertension in rats with chronic renal failure (CRF). The rise in central SNS activity is mitigated by increased local expression of neuronal nitric oxide synthase (NOS) mRNA and NO<jats:sub>2<\/jats:sub>\/NO<jats:sub>3<\/jats:sub>production. Because interleukin (IL)-1\u03b2 may activate nitric oxide in the brain, we have tested the hypothesis that IL-1\u03b2 may modulate the activity of the SNS via regulation of the local expression of neuronal NOS (nNOS) in the brain of CRF and control rats. To this end, we first found that administration of IL-1\u03b2 in the lateral ventricle of control and CRF rats decreased blood pressure and norepinephrine (NE) secretion from the posterior hypothalamus (PH) and increased NOS mRNA expression. Second, we observed that an acute or chronic injection of an IL-1\u03b2-specific antibody in the lateral ventricle raised blood pressure and NE secretion from the PH and decreased NOS mRNA abundance in the PH of control and CRF rats. Finally, we measured the IL-1\u03b2 mRNA abundance in the PH, locus coeruleus, and paraventricular nuclei of CRF and control rats by RT-PCR and found it to be greater in CRF rats than in control rats. In conclusion, these studies have shown that IL-1\u03b2 modulates the activity of the SNS in the central nervous system and that this modulation is mediated by increased local expression of nNOS mRNA.<\/jats:p>","DOI":"10.1152\/ajpheart.2000.279.6.h2786","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T09:13:52Z","timestamp":1513934032000},"page":"H2786-H2796","source":"Crossref","is-referenced-by-count":28,"title":["Interleukin-1\u03b2 and neurogenic control of blood pressure in normal rats and rats with chronic renal failure"],"prefix":"10.1152","volume":"279","author":[{"given":"Shaohua","family":"Ye","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Southern California, Los Angeles, California 90033"}]},{"given":"Pantea","family":"Mozayeni","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Southern California, Los Angeles, 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