{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:52:11Z","timestamp":1774565531961,"version":"3.50.1"},"reference-count":31,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,4,1]]},"abstract":"<jats:p> A multiple-breath washout technique was used to assess residual ventilation heterogeneity in the conductive and acinar lung zones of asthmatic patients after maximal \u03b2<jats:sub>2<\/jats:sub>-agonist reversibility. Reversibility was assessed in 13 patients on two separate visits corresponding to a different baseline condition in terms of forced expiratory volume in 1 s [FEV<jats:sub>1<\/jats:sub>; average FEV<jats:sub>1<\/jats:sub> over 2 visits: 92 \u00b1 21% of predicted (SE)]. On the visit corresponding to each patient's best baseline, 400 \u03bcg salbutamol led to normal acinar ventilation heterogeneity, normal FEV<jats:sub>1<\/jats:sub>, and normal peak expiratory flow; i.e., none was significantly different from that obtained in 13 matched controls. By contrast, conductive ventilation heterogeneity and forced expiratory flow after exhalation of 75% forced vital capacity remained significantly different from controls ( P \u2264 0.005 on both indexes). In addition, the degree of postdilation conductive ventilation heterogeneity was similar to what was previously obtained in asthmatic individuals with a 19% lower baseline FEV<jats:sub>1<\/jats:sub>and twofold larger acinar ventilation heterogeneity (Verbanck S, Schuermans D, Noppen M, Van Muylem A, Paiva M, and Vincken W. Am J Respir Crit Care Med 159: 1545\u20131550, 1999). We conclude that, even in the mildest forms of asthma, the most consistent pattern of non-\u03b2<jats:sub>2<\/jats:sub>-agonist-reversible ventilatory heterogeneity is in the conductive lung zone, most probably in the small conductive airways. <\/jats:p>","DOI":"10.1152\/japplphysiol.00588.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:44:35Z","timestamp":1425415475000},"page":"1380-1386","source":"Crossref","is-referenced-by-count":61,"title":["Nonreversible conductive airway ventilation  heterogeneity in mild asthma"],"prefix":"10.1152","volume":"94","author":[{"given":"Sylvia","family":"Verbanck","sequence":"first","affiliation":[{"name":"Respiratory Division, Academic Hospital, Vrije Universiteit Brussel, 1090 Brussels; and"}]},{"given":"Dani\u00ebl","family":"Schuermans","sequence":"additional","affiliation":[{"name":"Respiratory Division, Academic Hospital, Vrije Universiteit Brussel, 1090 Brussels; and"}]},{"given":"Manuel","family":"Paiva","sequence":"additional","affiliation":[{"name":"Biomedical Physics Laboratory, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}]},{"given":"Walter","family":"Vincken","sequence":"additional","affiliation":[{"name":"Respiratory Division, Academic Hospital, Vrije Universiteit Brussel, 1090 Brussels; and"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.4.248"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.4.1125"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197806082982303"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.3.838"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.5.1594"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.8.629"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.rsaa-6"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.1179"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173760"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.rsaa-intro"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9906075"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9709109"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9806079"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.6.9608027"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.12061346"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.5.2139"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.2.2008119"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.4.9909044"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.13367399"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.3.8630570"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.rsaa-5"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9704038"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1216"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.4.1040"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.3.1067"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9809017"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.83.6.1907"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.6.2587"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.3.584"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.rsaa-8"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)92153-R"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00588.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:23:39Z","timestamp":1567974219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00588.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,1]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4,1]]}},"alternative-id":["10.1152\/japplphysiol.00588.2002"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00588.2002","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,1]]}}}