{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:29:31Z","timestamp":1773289771337,"version":"3.50.1"},"reference-count":40,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>Repeated exposure to brief periods of hypoxia leads to pathophysiological changes in experimental animals similar to those seen in sleep apnea. To determine the effects of such exposure on oxygen levels in vivo, we used an optical method to measure Po<jats:sub>2<\/jats:sub>in microcirculatory vessels and tissue of the rat cremaster muscle during a 1-min step reduction of inspired oxygen fraction from 0.21 to 0.07. Under control conditions, Po<jats:sub>2<\/jats:sub>was 98.1 \u00b1 1.9 Torr in arterial blood, 52.2 \u00b1 2.8 Torr in 29.0 \u00b1 2.7-\u03bcm arterioles, 26.8 \u00b1 1.7 Torr in the tissue interstitium near venous capillaries, and 35.1 \u00b1 2.6 Torr in 29.7 \u00b1 1.9-\u03bcm venules. The initial fall in Po<jats:sub>2<\/jats:sub>during hypoxia was significantly greater in arterial blood, being 93% complete in the first 10 s, whereas it was 68% complete in arterioles, 47% at the tissue sites, and 38% in venules. In the 10- to 30-s period, the fall in normalized tissue and venular Po<jats:sub>2<\/jats:sub>was significantly greater than in arterial Po<jats:sub>2<\/jats:sub>. At the end of hypoxic exposure, Po<jats:sub>2<\/jats:sub>at all measurement sites had fallen very nearly in proportion to that in the inspired gas, but tissue oxygen levels did not reach critical Po<jats:sub>2<\/jats:sub>. Significant differences in oxyhemoglobin desaturation rate were also observed between arterial and microcirculatory vessels during hypoxia. In conclusion, the fall in microcirculatory and tissue oxygen levels in resting skeletal muscle is significantly slower than in arterial blood during a step reduction to an inspired oxygen fraction of 0.07, and tissue Po<jats:sub>2<\/jats:sub>does not reach anaerobic levels.<\/jats:p>","DOI":"10.1152\/japplphysiol.00591.2004","type":"journal-article","created":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T05:32:59Z","timestamp":1110951179000},"page":"1177-1184","source":"Crossref","is-referenced-by-count":33,"title":["Effect of acute hypoxia on microcirculatory and tissue oxygen levels in rat cremaster muscle"],"prefix":"10.1152","volume":"98","author":[{"given":"Paul C.","family":"Johnson","sequence":"first","affiliation":[]},{"given":"Kim","family":"Vandegriff","sequence":"additional","affiliation":[]},{"given":"Amy 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