{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:26:49Z","timestamp":1773757609522,"version":"3.50.1"},"reference-count":11,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p> A. C. Guyton pioneered major advances in understanding cardiovascular equilibrium. He superimposed venous return curves on cardiac output curves to reveal their intersection at the one level of right atrial pressure (Pra) and flow simultaneously consistent with independent properties of the heart and vasculature. He showed how this point would change with altered properties of the heart (e.g., contractility, sensitivity to preload) and\/or of the vasculature (e.g., resistance, total volume). In such graphical representations of negative feedback between two subdivisions of a system, one input\/output relationship is necessarily plotted backward, i.e., with the input variable on the y-axis (here, the venous return curve). Unfortunately, this format encourages mistaken ideas about the role of Pra as a \u201cback pressure,\u201d such as the assertion that elevating Pra to the level of mean systemic pressure would stop venous return. These concepts are reexamined through review of the original experiments on venous return, presentation of a hypothetical alternative way for obtaining the same data, and analysis of a simple model. <\/jats:p>","DOI":"10.1152\/japplphysiol.00868.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T15:44:02Z","timestamp":1425397442000},"page":"849-859","source":"Crossref","is-referenced-by-count":72,"title":["A critical analysis of the view that right atrial pressure determines venous return"],"prefix":"10.1152","volume":"94","author":[{"given":"George L.","family":"Brengelmann","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195-7290"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1986.251.2.H288"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1955.35.1.123"},{"key":"B5","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1152\/ajplegacy.1957.189.3.609","volume":"189","author":"Guyton AC","year":"1957","journal-title":"Am J Physiol"},{"key":"B6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1152\/ajplegacy.1955.180.3.463","volume":"180","author":"Guyton AC","year":"1955","journal-title":"Am J Physiol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.3.H1022"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.6.739"},{"key":"B9","first-page":"397","author":"Rothe CF.","year":"1983","journal-title":"Handbook of Physiology. The Cardiovascular System. Peripheral Circulation and Organ Blood Flow."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.2.499"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1994.267.6.H2378"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.1.H316"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BF02368608"}],"container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/japplphysiol.00868.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T16:24:54Z","timestamp":1567959894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/japplphysiol.00868.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,1]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3,1]]}},"alternative-id":["10.1152\/japplphysiol.00868.2002"],"URL":"https:\/\/doi.org\/10.1152\/japplphysiol.00868.2002","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,1]]}}}