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Twenty Long-Evans rats were anesthetized with isoflurane (1%, n = 10) or ketamine\/xylazine (50\/6 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup>\u00b7 h<jats:sup>\u22121<\/jats:sup>ip, n = 10) and imaged for 5\u201310 min in a 9.4 T MR scanner without experimental stimulation or task requirement. Independent, synchronous LFFs of BOLD signals were found to exist in clustered, bilaterally symmetric regions of both cortical and subcortical structures, including primary and secondary somatosensory cortices, motor cortices, visual cortices, posterior and anterior cingulate cortices, hippocampi, caudate-putamen, and thalamic and hypothalamic nuclei. The somatosensory and motor cortices typically demonstrated both symmetric and asymmetric components with unique frequency profiles. Similar independent network components were found under isoflurane and ketamine\/xylazine anesthesia. The report demonstrates, for the first time, 12 independent resting networks that are bilaterally synchronous in different cortical and subcortical areas of the rat brain.<\/jats:p>","DOI":"10.1152\/jn.00141.2010","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T02:35:03Z","timestamp":1271903703000},"page":"3398-3406","source":"Crossref","is-referenced-by-count":136,"title":["Functional Networks in the Anesthetized Rat Brain Revealed by Independent Component Analysis of Resting-State fMRI"],"prefix":"10.1152","volume":"103","author":[{"given":"R. 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