{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:00:02Z","timestamp":1759683602086,"version":"3.41.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neurophysiology"],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:p>Woodhall, Gavin, Christine E. Gee, Richard Robitaille, and Jean-Claude Lacaille. Membrane potential and intracellular Ca<jats:sup>2+<\/jats:sup>oscillations activated by mGluRs in hippocampal stratum oriens\/alveus interneurons. J. Neurophysiol. 81: 371\u2013382, 1999. Metabotropic glutamate receptors (mGluRs) are expressed heterogeneously in hippocampal interneurons, and their signal transduction cascades remain largely unclear. We characterized an oscillatory response activated by the mGluR agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in hippocampal interneurons of stratum oriens-alveus (OA) with simultaneous whole cell current-clamp recordings and intracellular Ca<jats:sup>2+<\/jats:sup>imaging with confocal microscopy. 1S,3R-ACPD induced oscillatory membrane depolarizations and rises in intracellular Ca<jats:sup>2+<\/jats:sup>that persisted in tetrodotoxin and were blocked by the antagonist of group I and II mGluRs (S)-\u03b1-methyl-4-carboxyphenylglycine. Membrane depolarizations and intracellular Ca<jats:sup>2+<\/jats:sup>rises were blocked by extracellular Cd<jats:sup>2+<\/jats:sup>and in Ca<jats:sup>2+<\/jats:sup>-free medium. mGluR responses therefore required Ca<jats:sup>2+<\/jats:sup>influx via voltage-gated Ca<jats:sup>2+<\/jats:sup>channels. 1S,3R-ACPD responses were also antagonized by depleting intracellular stores with thapsigargin and ryanodine, indicating that Ca<jats:sup>2+<\/jats:sup>release from intracellular stores was also necessary. These data suggest that oscillatory responses generated by group I\/II mGluRs involve a coupling of Ca<jats:sup>2+<\/jats:sup>entry through voltage-gated Ca<jats:sup>2+<\/jats:sup>channels and Ca<jats:sup>2+<\/jats:sup>release from internal stores. In contrast, 1S,3R-ACPD evoked only smaller depolarizations and intracellular Ca<jats:sup>2+<\/jats:sup>rises, with no oscillations, in other hippocampal interneurons located in or near stratum lacunosum-moleculare. Thus mGluR-mediated oscillatory responses are specifically expressed in certain interneuron subtypes. This heterogeneous expression of glutamate and Ca<jats:sup>2+<\/jats:sup>signaling pathways in specific interneurons may be relevant to their selective vulnerability to excitotoxicity.<\/jats:p>","DOI":"10.1152\/jn.1999.81.1.371","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T04:58:37Z","timestamp":1514177917000},"page":"371-382","source":"Crossref","is-referenced-by-count":49,"title":["Membrane Potential and Intracellular Ca<sup>2+<\/sup>Oscillations Activated by mGluRs in Hippocampal Stratum Oriens\/Alveus Interneurons"],"prefix":"10.1152","volume":"81","author":[{"given":"Gavin","family":"Woodhall","sequence":"first","affiliation":[{"name":"D\u00e9partement de Physiologie and Centre de Recherche en Sciences Neurologiques, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3C 3J7, Canada"}]},{"given":"Christine E.","family":"Gee","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Physiologie and Centre de Recherche en Sciences Neurologiques, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3C 3J7, Canada"}]},{"given":"Richard","family":"Robitaille","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Physiologie and Centre de Recherche en Sciences Neurologiques, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3C 3J7, Canada"}]},{"given":"Jean-Claude","family":"Lacaille","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Physiologie and Centre de Recherche en Sciences Neurologiques, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec H3C 3J7, Canada"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/385074a0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90086-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(91)90009-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296189"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb00638.x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/368823a0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(95)80012-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01520.x"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/382719a0"},{"key":"B10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0026-895X(25)08997-7","volume":"41","author":"Condorelli D. 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