{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:31:21Z","timestamp":1779179481635,"version":"3.51.4"},"reference-count":120,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Lipid rafts are liquid-ordered (l<jats:sub>o<\/jats:sub>) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l<jats:sub>o<\/jats:sub>-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.<\/jats:p>","DOI":"10.1152\/physiol.00032.2006","type":"journal-article","created":{"date-parts":[[2006,11,22]],"date-time":"2006-11-22T00:59:30Z","timestamp":1164157170000},"page":"430-439","source":"Crossref","is-referenced-by-count":324,"title":["Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals"],"prefix":"10.1152","volume":"21","author":[{"given":"Deborah A.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1021\/bi971167g"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1021\/bi001039j"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1485"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.4.2068"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/ni1202"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.43.28478"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020774"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.5887"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2005.11.007"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.10.5500-5506.2004"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01469-05"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03784-5"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.14.1.111"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90189-J"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.19.10556-10565.2004"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8374-8387.2005"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.2.226-237.2003"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.21.13673-13684.2005"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200512116"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.3693"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1080\/09687860500460041"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404410200"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.1.108-118.2006"},{"key":"R25","doi-asserted-by":"crossref","unstructured":"Christian AE, Haynes MP, Phillips MC, and Rothblat GH. Use of cyclodextrins for manipulating cellular cholesterol content.J Lipid Res38: 2264\u20132272, 1997.","DOI":"10.1016\/S0022-2275(20)34940-3"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.6.3749-3758.2003"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411987200"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)76114-0"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.009"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141021"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1021\/bi060245+"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1021\/bi034718d"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.3.1753"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.2.913"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305006"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505047"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1042\/BST0320673"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1103"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2123"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.05.012"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405654102"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1925"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.2.199"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.05.008"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75278-8"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00504-7"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02296"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg177"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.06.007"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.7.6.843"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77369-8"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.2.447"},{"key":"R53","doi-asserted-by":"crossref","unstructured":"Jing SQ and Trowbridge IS. Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake.J Biol Chem265: 11555\u201311559, 1990.","DOI":"10.1016\/S0021-9258(19)38433-9"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.6.1357"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200312170"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.5.1645"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.06.002"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg095"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.10.001"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00515.x"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physchem.56.092503.141211"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.09.066"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.07.007"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.23.11845-11852.2002"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.28861"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(03)00015-4"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)74595-0"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1704"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1021\/bi00049a031"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.6.3910"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1021\/bi015574a"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.3.2191"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.18.5334"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.6.1271"},{"key":"R75","doi-asserted-by":"crossref","unstructured":"Neame SJ, Uff CR, Sheikh H, Wheatley SC, and Isacke CM. CD44 exhibits a cell type dependent interaction with Triton X-100 insoluble, lipid rich, plasma membrane domains.J Cell Sci108: 3127\u20133135, 1995.","DOI":"10.1242\/jcs.108.9.3127"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200109059"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.008607"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.48.34459"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02853"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.06.009"},{"key":"R81","doi-asserted-by":"crossref","unstructured":"Perschl A, Lesley J, English N, Hyman R, and Trowbridge IS. Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts.J Cell Sci108: 1033\u20131041, 1995.","DOI":"10.1242\/jcs.108.3.1033"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R200021-JLR200"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.06.004"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504114102"},{"key":"R85","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306380200"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.12740"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)76185-1"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1331629100"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-06-0480"},{"key":"R90","doi-asserted-by":"crossref","unstructured":"Romanenko VG, Rothblat GH, and Levitan I. Sensitivity of volume-regulated anion current to cholesterol structural analogues.J Gen Physiol123: 77\u201388, 2003.","DOI":"10.1085\/jgp.200308882"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1038\/35023524"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.240459697"},{"key":"R93","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602818103"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.18.5501"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.12130"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0631579100"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00167-9"},{"key":"R98","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.4.877"},{"key":"R99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500247200"},{"key":"R100","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020143"},{"key":"R101","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)74542-1"},{"key":"R102","doi-asserted-by":"publisher","DOI":"10.1021\/bi9615506"},{"key":"R103","doi-asserted-by":"publisher","DOI":"10.1021\/bi00417a001"},{"key":"R104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509858103"},{"key":"R105","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9219.2003.0138.x"},{"key":"R106","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.01.076"},{"key":"R107","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.125.4.795"},{"key":"R108","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02939-3"},{"key":"R109","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2005.06.010"},{"key":"R110","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.062380"},{"key":"R111","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5402.680"},{"key":"R112","doi-asserted-by":"publisher","DOI":"10.1021\/bi0112311"},{"key":"R113","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.141.4.917"},{"key":"R114","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80577-4"},{"key":"R115","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104776200"},{"key":"R116","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200277200"},{"key":"R117","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009852200"},{"key":"R118","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2237224100"},{"key":"R119","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408339200"},{"key":"R120","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068539"},{"key":"R121","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80606-8"}],"container-title":["Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiol.00032.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T23:44:31Z","timestamp":1628120671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiol.00032.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":120,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1152\/physiol.00032.2006"],"URL":"https:\/\/doi.org\/10.1152\/physiol.00032.2006","relation":{},"ISSN":["1548-9213","1548-9221"],"issn-type":[{"value":"1548-9213","type":"print"},{"value":"1548-9221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}