{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:03:06Z","timestamp":1785416586218,"version":"3.56.0"},"reference-count":81,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Advances in Physiology Education"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>This study explores the use of the chick embryo model as a teaching aid to illustrate connections between anatomy and physiology during development. Providing direct observation opportunities, the model allows students to witness organ formation and the impact of teratogens, focusing on cardiovascular abnormalities associated with fetal alcohol syndrome. The paper outlines practical methodologies to assess developmental outcomes. Its adaptability, affordability, and ability to spark discussions make the model a valuable resource for diverse educational environments.<\/jats:p>","DOI":"10.1152\/advan.00195.2024","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T06:11:02Z","timestamp":1741587062000},"page":"438-460","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The chick embryo model as an educational tool to explore the effect of alcohol on cardiovascular development"],"prefix":"10.1152","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-2238","authenticated-orcid":false,"given":"Declan","family":"McLaughlin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hswnk62","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University Belfast","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9194-360X","authenticated-orcid":false,"given":"Aisling","family":"Keane","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hswnk62","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University Belfast","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Quinn","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hswnk62","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University Belfast","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuala","family":"Tipping","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00hswnk62","id-type":"ROR","asserted-by":"publisher"}],"name":"Queen\u2019s University Belfast","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00121.2018"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-012-0198-3"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00224"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2016.01.007"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/tera.10093"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.04.010"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.03.008"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001950404"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1242\/dev.51.1.227"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/s0012-1606(81)80007-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00318980"},{"key":"B12","volume-title":"Atlas of Chick Development","author":"Bellairs R","year":"2005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2007.00769.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.170268ks"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2004.05.015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.170315CT"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.170312cm"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091751"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-120417-031559"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24093"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2016.05.003"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101499"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12286"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1086\/670594"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022016000400002"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01034"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00107.2002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01574"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(98)00218-1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-CM-18-000061"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-87779-8_8"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43961-3_2"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/ase.2505"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2017-0205"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20597"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2007.12.007"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.080"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.666726"},{"key":"B39","unstructured":"UK Department of Health. How to keep health risks from drinking alcohol to a low level. Government response to the public consultation. 2016. https:\/\/assets.publishing.service.gov.uk\/media\/5a74a8b040f0b619c8659639\/GovResponse2.pdf [2024 Aug 5]."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015410"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20461"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01664.x"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e31827f238f"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.120220"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01679.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.10.004"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2004.00280.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.17061\/phrp2521516"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21129"},{"key":"B50","unstructured":"National Health Service. NHS Overview. Congenital Heart Disease. https:\/\/www.nhs.uk\/conditions\/congenital-heart-disease\/ [2024 Aug 5]."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30402-X"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2007.00105.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130681"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph7020364"},{"key":"B55","unstructured":"British Medical Association. Alcohol and pregnancy. Preventing and managing fetal alcohol spectrum disorders. 2016. https:\/\/www.bma.org.uk\/media\/2082\/fetal-alcohol-spectrum-disorders-report-feb2016.pdf [2024 Aug 5]."},{"key":"B56","unstructured":"Centre for Disease Control and Prevention. Data and statistics on FASDs. https:\/\/www.cdc.gov\/fasd\/data\/index.html [2024 Aug 5]."},{"key":"B57","first-page":"54","volume":"64","author":"Fox DJ","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.08.006"},{"key":"B59","unstructured":"UK Government Department of Health and Social Care. Guidance; fetal alcohol spectrum disorder: health needs assessment. 2021. https:\/\/www.gov.uk\/government\/publications\/fetal-alcohol-spectrum-disorder-health-needs-assessment\/fetal-alcohol-spectrum-disorder-health-needs-assessment [2024 Aug 5]."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0066"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1177\/0308575915594985"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-242-7_6"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1515\/9783110858242-043"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20202"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04612.x"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2016.04.020"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20468"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2012.10.011"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00105-X"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2022.106963"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0256"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10145"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12087"},{"key":"B74","first-page":"1227","volume":"66","author":"Kamran K","year":"2016","journal-title":"J Pak Med Assoc"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2017.06.014"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2011.00331.x"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1177\/0033354916662222"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/cch.12187"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2018.06.002"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200408000-00002"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2011.05.021"}],"container-title":["Advances in Physiology Education"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/advan.00195.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T20:10:00Z","timestamp":1767384600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/advan.00195.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":81,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1152\/advan.00195.2024"],"URL":"https:\/\/doi.org\/10.1152\/advan.00195.2024","relation":{},"ISSN":["1043-4046","1522-1229"],"issn-type":[{"value":"1043-4046","type":"print"},{"value":"1522-1229","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]},"assertion":[{"value":"2024-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}