{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:01:18Z","timestamp":1792810878381,"version":"4.5.0"},"reference-count":43,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100017995","name":"Nora Eccles Treadwell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03DK129958-01"],"award-info":[{"award-number":["R03DK129958-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["3-SRA-2025-1634-S-B"],"award-info":[{"award-number":["3-SRA-2025-1634-S-B"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["1-SRA-2025-1635-S-B"],"award-info":[{"award-number":["1-SRA-2025-1635-S-B"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>This study provides the first quantitative evidence that human stem cell-derived islets are more resistant to hypoxia than primary human islets. Stem cell-derived islets maintain viability at substantially lower oxygen levels and exhibit markedly reduced variability in hypoxia tolerance. These findings identify hypoxia resistance as a key functional advantage of stem cell-derived islets, with important implications for transplantation into low-oxygen environments and for scalable islet fabrication strategies.<\/jats:p>","DOI":"10.1152\/ajpcell.00043.2026","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:00:34Z","timestamp":1774285234000},"page":"C1237-C1245","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced hypoxia resistance distinguishes human pluripotent stem cell-derived islets from primary islets"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-7663","authenticated-orcid":false,"given":"Hiroyuki","family":"Kato","sequence":"first","affiliation":[{"name":"University of California, San Francisco","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-7607","authenticated-orcid":false,"given":"Kuang-Ming","family":"Shang","sequence":"additional","affiliation":[{"name":"California Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-1482","authenticated-orcid":false,"given":"Hiroaki","family":"Mitsugashira","sequence":"additional","affiliation":[{"name":"University of California, San Francisco","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirigeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Arthur Riggs Diabetes & Metabolism Research Institute of City of Hope","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoharu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Kyoto University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-0167","authenticated-orcid":false,"given":"Peter G.","family":"Stock","sequence":"additional","affiliation":[{"name":"University of California, San Francisco","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-0525","authenticated-orcid":false,"given":"Taro","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Kyoto University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chong","family":"Tai","sequence":"additional","affiliation":[{"name":"California Institute of Technology","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Kandeel","sequence":"additional","affiliation":[{"name":"Arthur Riggs Diabetes & Metabolism Research Institute of City of Hope","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-4809","authenticated-orcid":false,"given":"Hirotake","family":"Komatsu","sequence":"additional","affiliation":[{"name":"University of California, San Francisco","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01258.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2574"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.08.022"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c160050"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00017.2012"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001050"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00984.2024"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.66"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.9.1161"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430401"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061267"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2503822"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00154"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.10.002"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020914"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.10.005"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00024.2024"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/srep03594"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08753-5"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09124-w"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-017-9659-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000574"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0055"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4784-y"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1177\/09636897211052291"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aca79a"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X689721"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1177\/0963689720919444"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1015063"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110739"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/widm.2"},{"key":"B32","doi-asserted-by":"publisher","unstructured":"Bradley K, Moore C, Ishahak M, Maestas MM, Veronese-Paniagua DA, Millman JR. Divergent cell-type specific hypoxia responses in human stem cell-derived and primary islets (Preprint). bioRxiv, 2025. doi:10.1101\/2025.07.16.665006. 40777266","DOI":"10.1101\/2025.07.16.665006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59924-7"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.07.012"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1685-0"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/414807a"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694054"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-008-9107-3"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911423654"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16323"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183780"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0001122912.40519.44"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00043.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:44:04Z","timestamp":1780325044000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00043.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1152\/ajpcell.00043.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00043.2026","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}