{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T19:43:55Z","timestamp":1767383035867,"version":"3.37.3"},"reference-count":37,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"INCT Nano-Biofarmac\u00eautica"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["TEC-RED-00282-16","RED-00081-23, RED-00202-22"],"award-info":[{"award-number":["TEC-RED-00282-16","RED-00081-23, RED-00202-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UFMG | Pr\u00f3-Reitoria de Pesquisa, Universidade Federal de Minas Gerais"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p> Alamandine, a member of the renin-angiotensin system, serves critical roles in cardioprotection, including the modulation of cardiomyocyte contractility. Whether this effect varies along the day is unknown. Our results provide evidence that alamandine via receptor MrgD exerts opposing actions on cardiomyocyte shortening, enhancing, or reducing contraction depending on the time of day. These findings may have significant implications for the development and effectiveness of future cardiac therapies. <\/jats:p>","DOI":"10.1152\/ajpcell.00049.2024","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T19:08:02Z","timestamp":1724094482000},"page":"C1143-C1149","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Time of day affects MrgD-dependent modulation of cardiomyocyte contractility"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-9145","authenticated-orcid":false,"given":"Andr\u00e9 L. L.","family":"Monteiro","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"INCT Nanobiofarmac\u00eautica, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Eliezeck","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio R. A.","family":"Scalzo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio Morais","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"INCT Nanobiofarmac\u00eautica, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-609X","authenticated-orcid":false,"given":"Bruno","family":"Sanches","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"INCT Nanobiofarmac\u00eautica, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0550-3913","authenticated-orcid":false,"given":"Katyana K. S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-889X","authenticated-orcid":false,"given":"Maristela O.","family":"Poletini","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-1593","authenticated-orcid":false,"given":"Rodrigo A.","family":"Peliciari-Garcia","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de S\u00e3o Paulo, Diadema, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00eafany B. A.","family":"Cau","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5852","authenticated-orcid":false,"given":"Robson A.","family":"Souza Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"INCT Nanobiofarmac\u00eautica, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8386-3722","authenticated-orcid":false,"given":"Silvia","family":"Guatimosim","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"},{"name":"INCT Nanobiofarmac\u00eautica, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2017"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.85.7.643"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00881.2010"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/1753944716642677"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0244-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00723.2018"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2016"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301077"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00153.2017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00399.2021"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00153.2019"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01291.2007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1081\/cbi-100101071"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-014-0973-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12210"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000039960.66987.89"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/BF00340536"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.5.C1327"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00142.2020"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.199539"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E21-03-0130"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100441R"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0167-4"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.03.024"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82202-7"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314240200"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3509-12.2012"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12306"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.05.031"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178769"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800615RR"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4932-06.2007"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07572"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03668-3"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01179"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1081\/cbi-120002915"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.02.013"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00049.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:17:26Z","timestamp":1728922646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00049.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1152\/ajpcell.00049.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00049.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"type":"print","value":"0363-6143"},{"type":"electronic","value":"1522-1563"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"2024-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}