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Herein, we demonstrate that mice lacking myeloid hypoxia-inducible factor 1A (HIF1A) develop an exacerbated lung injury response to bleomycin that was consistent with reduced macrophage HIF1A expression in nonresolvable (NR)-COVID-19, characterized by extensive lung fibrosis.<\/jats:p>","DOI":"10.1152\/ajpcell.00060.2025","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:00:03Z","timestamp":1761411603000},"page":"C1752-C1764","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Decoding fibrosis in nonresolvable COVID-19: a role for myeloid-specific HIF1A deletion"],"prefix":"10.1152","volume":"329","author":[{"given":"Kemly","family":"Philip","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center at Houston","place":["United 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