{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:02:58Z","timestamp":1792814578699,"version":"4.5.0"},"reference-count":69,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18PRE33960162"],"award-info":[{"award-number":["18PRE33960162"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19TPA34850131"],"award-info":[{"award-number":["19TPA34850131"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["900431"],"award-info":[{"award-number":["900431"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["903250"],"award-info":[{"award-number":["903250"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23PRE1012811"],"award-info":[{"award-number":["23PRE1012811"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL146562"],"award-info":[{"award-number":["R01 HL146562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["T32 AG020494"],"award-info":[{"award-number":["T32 AG020494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:p>This is the first study to test whether trophoblast cells release mitochondrial (mt)DNA in response to oxidative stress and to identify mechanisms of release and biological forms of mtDNA from this cellular type. This research identifies potential cellular mechanisms that can be used in future investigations to establish the source and biomarker potential of circulating mtDNA in preclinical experimental models and humans.<\/jats:p>","DOI":"10.1152\/ajpcell.00091.2024","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:20:08Z","timestamp":1715574008000},"page":"C1776-C1788","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells"],"prefix":"10.1152","volume":"326","author":[{"given":"Jennifer J.","family":"Gardner","sequence":"first","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-8994","authenticated-orcid":false,"given":"Spencer C.","family":"Cushen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States"},{"name":"Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene\u00e9 de Nazar\u00e9","family":"Oliveira da Silva","sequence":"additional","affiliation":[{"name":"Lawrence D. Longo, MD Center for Perinatal Biology, Departments of Basic Sciences, Gynecology, and Obstetrics, Loma Linda University School of Medicine, Loma Linda, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4011-8401","authenticated-orcid":false,"given":"Jessica L.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4923-6589","authenticated-orcid":false,"given":"Nataliia","family":"Hula","sequence":"additional","affiliation":[{"name":"Lawrence D. Longo, MD Center for Perinatal Biology, Departments of Basic Sciences, Gynecology, and Obstetrics, Loma Linda University School of Medicine, Loma Linda, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle K.","family":"Gorham","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-8716","authenticated-orcid":false,"given":"Selina M.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Population & Community Health, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-5516","authenticated-orcid":false,"given":"Rebecca L.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-8256","authenticated-orcid":false,"given":"Styliani","family":"Goulopoulou","sequence":"additional","affiliation":[{"name":"Lawrence D. Longo, MD Center for Perinatal Biology, Departments of Basic Sciences, Gynecology, and Obstetrics, Loma Linda University School of Medicine, Loma Linda, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy049"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.09.047"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.121798"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.06.038"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.21"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00324.2019"},{"key":"B7","first-page":"237","volume":"3","author":"Qiu C","year":"2012","journal-title":"Int J Mol Epidemiol Genet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.10.003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118804410"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021726"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.04.002"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051159"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001577"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2019.05.015"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112898"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav4011"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.014"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0870-5"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00322.2022"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/srep03887"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15153866"},{"key":"B23","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-573543"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-018-0954-3"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2856"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaz032"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2018-123"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901917RR"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062122"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2015.02.006"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.05.027"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16448-5"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11290"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.239"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4188"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)60432-4"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-020-0528-8"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1320"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2010.09.001"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2022.103766"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229332"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei272"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2023.03.006"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507397112"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.09.003"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1781-9"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169076"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-032620-104401"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023028"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.07.006"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040957"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108319159"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000366"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.10.009"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245155"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1472"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105644"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091865"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.01.002"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2023.09.010"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99837-1"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0360-0"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201700037"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01670-0"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.11.023"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3801"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-020-03004-w"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0526"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00091.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T12:17:36Z","timestamp":1718713056000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00091.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":69,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,1]]}},"alternative-id":["10.1152\/ajpcell.00091.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00091.2024","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.02.02.578433","asserted-by":"object"}]},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,1]]},"assertion":[{"value":"2024-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}