{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:51:17Z","timestamp":1780671077829,"version":"3.54.1"},"reference-count":87,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL-132908"],"award-info":[{"award-number":["HL-132908"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:p> Endothelial cells, macrophages, and fibroblasts metabolize substance P (SP) to N- and C-terminal metabolites with SP 5\u201311 as the most abundant metabolite. SP activates neurokinin-1 receptors to increase intracellular calcium and cyclic AMP. In contrast, SP metabolites of N-terminal metabolism and C-terminal deamidation retain the ability to increase calcium but lose the ability to increase cyclic AMP. These new insights indicate that the metabolism of SP directs cellular functions by regulating specific signaling pathways. <\/jats:p>","DOI":"10.1152\/ajpcell.00103.2024","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T08:01:24Z","timestamp":1716796884000},"page":"C151-C167","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cellular metabolism of substance P produces neurokinin-1 receptor peptide agonists with diminished cyclic AMP signaling"],"prefix":"10.1152","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-0076","authenticated-orcid":false,"given":"Tamas","family":"Kriska","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayashree","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-6377","authenticated-orcid":false,"given":"Anja","family":"Herrnreiter","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Widiapradja","sequence":"additional","affiliation":[{"name":"Robert C. Byrd Health Sciences Center, Department of Physiology and Pharmacology, West Virginia University, Morgantown, Virginia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-4942","authenticated-orcid":false,"given":"Scott P.","family":"Levick","sequence":"additional","affiliation":[{"name":"Robert C. Byrd Health Sciences Center, Department of Physiology and Pharmacology, West Virginia University, Morgantown, Virginia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092682"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.03.006"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2019.101941"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.9.2.333-340.2002"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1284"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.11.010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.07.190"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47369-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1645\/GE-596R1.1"},{"key":"B11","first-page":"76","volume":"2","author":"Robinson P","year":"2009","journal-title":"Int J Clin Exp Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/645153"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.08.003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1959270"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000163"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0255"},{"key":"B17","first-page":"121","volume":"16","author":"Mak IT","year":"2011","journal-title":"Exp Clin Cardiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.74.5.1009"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.05.113"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.556274"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00010-0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00200.2015"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114365"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102659"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.05.014"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602563103"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806632105"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0535-8"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12642"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001297"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17824"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.10.005"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1021\/cb200248h"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.5.H1525"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00553-5"},{"key":"B36","first-page":"1039","volume":"276","author":"Sagan S","year":"1996","journal-title":"J Pharmacol Exp Ther"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(78)81210-1"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08051.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(84)90020-2"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb17168.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.7.4053"},{"key":"B42","first-page":"1865","volume":"27","author":"Diekmann O","year":"1994","journal-title":"Braz J Med Biol Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.64031312.x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(85)90243-7"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)38586-2"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065x.1998.tb01577.x"},{"key":"B47","first-page":"551","volume":"46","author":"Regoli D","year":"1994","journal-title":"Pharmacol Rev"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115975"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12931"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(94)90212-7"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a135166"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2746"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.06.002"},{"key":"B54","first-page":"968","volume":"259","author":"Ingi T","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.12.7646"},{"key":"B56","first-page":"1096","volume":"41","author":"Cascoeri MA","year":"1992","journal-title":"Mol Pharmacol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02767"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100621200"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00890-8"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07408.x"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.12659\/msm.898454"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.7.4392"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(85)90262-9"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.5.L1257"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.159.11.5450"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.038620"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00475.2005"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00747.2001"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.8.5785"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.12.3542"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(94)00228-7"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)67202-3"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85816-7"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34812-3"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110175"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.028951"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(02)00703-1"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.12.014"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000018127.10968.34"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00129.2008"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076140"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18348"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12053"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.799"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv142"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.70.2.271"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1991.tb00452.x"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00103.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T16:25:48Z","timestamp":1721233548000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00103.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["10.1152\/ajpcell.00103.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00103.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"assertion":[{"value":"2024-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}