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We used cDNA microarrays to compare the expression profile of 1,082 genes, previously selected by a subtractive method, in control and mdx hindlimb and diaphragm muscles at 12 time points over the first year of the mouse life. We determined that 1) the dystrophin gene defect induced marked expression remodeling of 112 genes encoding proteins implicated in diverse muscle cell functions and 2) two-thirds of the observed transcriptomal anomalies differed between adult mdx hindlimb and diaphragm muscles. Our results showed that neither mdx diaphram muscle nor mdx hindlimb muscles evolve entirely like the human DMD muscles. This finding should be taken under consideration for the interpretation of future experiments using mdx mice as a model for therapeutic assays. <\/jats:p>","DOI":"10.1152\/ajpcell.00112.2002","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:10:14Z","timestamp":1368490214000},"page":"C773-C784","source":"Crossref","is-referenced-by-count":48,"title":["Global\/temporal gene expression in diaphragm and  hindlimb muscles of dystrophin-deficient (<i>mdx<\/i>) mice"],"prefix":"10.1152","volume":"283","author":[{"given":"Karl","family":"Rouger","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 Mixte de Recherche (UMR) 533, Facult\u00e9 de M\u00e9decine, 44093 Nantes;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Le Cunff","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale 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