{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:19:34Z","timestamp":1787930374280,"version":"build-2784847793"},"reference-count":71,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL180318"],"award-info":[{"award-number":["HL180318"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL158532"],"award-info":[{"award-number":["HL158532"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL056470"],"award-info":[{"award-number":["HL056470"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL160570"],"award-info":[{"award-number":["HL160570"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL171915"],"award-info":[{"award-number":["HL171915"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"HHS | NIH | National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["EB022641"],"award-info":[{"award-number":["EB022641"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Massachusetts IALS Translational Graduate Student Fellowship"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>siRNA delivery to target cellular processes is an appealing area in lung diseases such as asthma. To realize this potential requires efficient, targeted cytosolic delivery without cellular toxicity or siRNA degradation. We demonstrate the efficacy of PONI-Guan nanoparticles in accessing airway epithelial and smooth muscle cells with specific siRNA targeting of mRNAs of interest while maintaining barrier integrity and avoiding cellular toxicity.<\/jats:p>","DOI":"10.1152\/ajpcell.00127.2026","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:12:22Z","timestamp":1786331542000},"page":"C783-C796","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells"],"prefix":"10.1152","volume":"331","author":[{"given":"Michael A.","family":"Thompson","sequence":"first","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-2906","authenticated-orcid":false,"given":"Samantha K.","family":"Hamrick","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-8798","authenticated-orcid":false,"given":"Niyati A.","family":"Borkar","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-5746","authenticated-orcid":false,"given":"Preetham","family":"Ravi","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3987-6969","authenticated-orcid":false,"given":"Yagiz Anil","family":"Cicek","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Lehot","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-6322","authenticated-orcid":false,"given":"Ritabrita","family":"Goswami","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-9126","authenticated-orcid":false,"given":"Harini","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9567-1140","authenticated-orcid":false,"given":"Nourina","family":"Nasim","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-5439","authenticated-orcid":false,"given":"Vincent M.","family":"Rotello","sequence":"additional","affiliation":[{"name":"University of Massachusetts","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-2174","authenticated-orcid":false,"given":"Christina M.","family":"Pabelick","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]},{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-224X","authenticated-orcid":false,"given":"Y. S.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["United States"]},{"name":"Mayo Clinic","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00259.2013"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611-2248ST"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202304-0642ST"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.05.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5b02428"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.020"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01854-8"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-019-0591-y"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.06.001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-16555-4_1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10003"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214427"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21571"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2019-0012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.02.006"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/1479-0556-6-7"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091996"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr06382j"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.08.002"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.04.008"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1039\/c6cs00636a"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1543"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02989-4"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c08690"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c03778"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06768"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.04.010"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057710"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.210138"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.627503"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00018.2012"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000329540"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0286-7"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.12.047"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044343"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01356.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.02.006"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00414.2015"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801002R"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00580.2016"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-68748-9_7"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-758OC"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01586.x"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01249.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023662"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00122.2021"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-025-03884-6"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/ajrcmb\/aanag058"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.11.011"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00322.2010"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/793186"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.11.014"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-13-11"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.002"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0176-2021"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02971.x"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2332627"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14782"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202406763"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1245-1"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0124OC"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00248.2024"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201002-0185OC"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2008.02.002"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.12.053"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17912"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00025.2009"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0151OC"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46022-6"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.6.9803023"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00127.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:29:18Z","timestamp":1787927358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00127.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/ajpcell.00127.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00127.2026","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}