{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:23:50Z","timestamp":1792268630900,"version":"4.4.0"},"reference-count":38,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM0290906"],"award-info":[{"award-number":["R01GM0290906"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["F32HL170637"],"award-info":[{"award-number":["F32HL170637"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","award":["21CVD02"],"award-info":[{"award-number":["21CVD02"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>This study shows that adult Burmese pythons can not only undergo reversible cardiomyocyte hypertrophy after feeding but can also activate cardiomyocyte cell-cycle re-entry and achieve hyperplasia, especially with frequent large meal consumption. Frequent feeding amplifies proliferation by engaging E2F and FOXM1 pro-proliferative signaling, resulting in sustained heart growth through hyperplasia in adult python hearts. These findings establish Burmese pythons as a new model for proliferative cardiac remodeling with potential insights into adult heart regenerative biology.<\/jats:p>","DOI":"10.1152\/ajpcell.00139.2026","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:01:58Z","timestamp":1784073718000},"page":"C641-C652","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic cardiac hyperplasia and hypertrophy in Burmese pythons"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-116X","authenticated-orcid":false,"given":"Yuxiao","family":"Tan","sequence":"first","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]},{"name":"University of Colorado Boulder","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1300-4890","authenticated-orcid":false,"given":"Thomas G.","family":"Martin","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-2511","authenticated-orcid":false,"given":"Angela K.","family":"Peter","sequence":"additional","affiliation":[{"name":"Edgewise Therapeutics","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Ozeroff","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]},{"name":"University of Colorado Boulder","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7940-6190","authenticated-orcid":false,"given":"Christopher C.","family":"Ebmeier","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Doptis","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Harrison","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-4810","authenticated-orcid":false,"given":"Leslie A.","family":"Leinwand","sequence":"additional","affiliation":[{"name":"University of Colorado Boulder","place":["United States"]},{"name":"University of Colorado Boulder","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0007-y"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200708"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315862"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164680"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.026"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/27131"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210558"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2408719121"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/434037a"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.49.2.560"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077857"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-023-00314-2"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2038"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.20850"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.70015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315408"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.01.021"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.034"},{"key":"B22","doi-asserted-by":"publisher","unstructured":"Martin TG, Suarez-Artiles L, Woulfe KC, Melhedegaard EG, Tan Y, Hunt DR, Kirkpatrick BE, Nguyen L, Lee J, Laskey I, Anseth KS, Ochala J, Gotthardt M, Mertins P, Leinwand LA. Multi-omics insight into cardiac myofibril remodeling in post-prandial Burmese pythons (Preprint). bioRxiv, 2026. doi:10.64898\/2026.02.02.703272. 41676733","DOI":"10.64898\/2026.02.02.703272"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00025.2023"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nature08899"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.09.005"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511209112"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.05.014"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84679"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201163"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59169-4"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.277442"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.065763"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00902-2"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3897\/neobiota.78.93788"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.160012"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1242\/dev.010363"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.250083"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.030999"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00139.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T22:16:35Z","timestamp":1787177795000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00139.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/ajpcell.00139.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00139.2026","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}