{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:08:27Z","timestamp":1789607307918,"version":"build-2803163510"},"reference-count":67,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","award":["2-6"],"award-info":[{"award-number":["2-6"]}],"id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H03292"],"award-info":[{"award-number":["JP21H03292"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p> The mechanisms underlying the disruption of excitation-contraction (EC) coupling in dystrophin-deficient muscles are not well understood. Here, using animal models for Duchenne muscular dystrophies (DMD), we show a Ca<jats:sup>2+<\/jats:sup>-dependent protease (calpain-1)-mediated proteolysis of SH3 and cysteine-rich domain 3 (STAC3) and junctophilin 1 (JP1), essential EC coupling proteins, in dystrophin-deficient muscle, and highlighting the dissociation of STAC3 and JP1 from dihydropyridine receptor as a causative factor in EC uncoupling of dystrophic muscles. <\/jats:p>","DOI":"10.1152\/ajpcell.00163.2022","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T11:16:23Z","timestamp":1659352583000},"page":"C885-C895","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Dissociation of SH3 and cysteine-rich domain 3 and junctophilin 1 from dihydropyridine receptor in dystrophin-deficient muscles"],"prefix":"10.1152","volume":"323","author":[{"given":"Yuki","family":"Ashida","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan"},{"name":"Japan Society for the Promotion of Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Himori","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan"},{"name":"Japan Society for the Promotion of Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Tokuda","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azuma","family":"Naito","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Takenaka-Ninagawa","sequence":"additional","affiliation":[{"name":"Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-7506","authenticated-orcid":false,"given":"Yoshitsugu","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5383-9366","authenticated-orcid":false,"given":"Hidetoshi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3880","authenticated-orcid":false,"given":"Takashi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences, Sapporo Medical University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01242.2001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2015"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00128.2007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2009.052019"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.160507"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.061291"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.075275"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00087.2009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00428.2009"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802217105"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.089318"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp021056"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.082180"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00469.2005"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00291.2005"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00008.2009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.4.C1325"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/335735a0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.859ab.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(76)90175-3"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90195-6"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(92)90045-a"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.243279"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2952"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310571110"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711917"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708852114"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612441113"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00463.2021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00270.2016"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13582"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7328"},{"key":"B33","first-page":"835","volume":"45","author":"Den Dunnen JT","year":"1989","journal-title":"Am J Hum Genet"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.186"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.12.191"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.06.004"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100092"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00445.2018"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012188"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1113\/JP276026"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25805"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.05.005"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018380108"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00861.2021"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-021-00668-x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.01.022"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.06.003"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1976.9999"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-014-9378-9"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/art.41594"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.8.3710"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-020-0221-2"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.080709"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)90068-x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021259"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/346567a0"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2008.05130.x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6397"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-020-00610-x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.12.004"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100874"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.292755"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716649115"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716461115"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2002"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.07.024"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit319"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00163.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T15:12:03Z","timestamp":1718637123000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00163.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["10.1152\/ajpcell.00163.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00163.2022","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2022-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}