{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:05:26Z","timestamp":1793315126523,"version":"4.5.0"},"reference-count":42,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R56HL163554"],"award-info":[{"award-number":["R56HL163554"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R00HL141583"],"award-info":[{"award-number":["R00HL141583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Texas Health Science Center at Tyler","award":["seed grant"],"award-info":[{"award-number":["seed grant"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p> MARCH8 is an important modulator of inflammation, immunity, and other cellular processes. We found that MARCH8 expression is downregulated in the lungs of patients with idiopathic pulmonary fibrosis (IPF) and experimental models of pulmonary fibrosis. Furthermore, TGF-\u03b21 decreases MARCH8 transcriptionally in human lung fibroblasts (HLFs). MARCH8 overexpression blunts TGF-\u03b21-induced fibroblast to myofibroblast transition while knockdown of MARCH8 drives this profibrotic change in HLFs. The findings support further exploration of MARCH8 as a novel target in IPF. <\/jats:p>","DOI":"10.1152\/ajpcell.00166.2023","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:15:31Z","timestamp":1693815331000},"page":"C1190-C1200","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["MARCH8 downregulation modulates profibrotic responses including myofibroblast differentiation"],"prefix":"10.1152","volume":"325","author":[{"given":"Xia","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4824-6766","authenticated-orcid":false,"given":"Oluwaseun","family":"Adeyanju","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayobami Matthew","family":"Olajuyin","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-478X","authenticated-orcid":false,"given":"Venkatakirankumar","family":"Mandlem","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christudas","family":"Sunil","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Adewumi","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-6331","authenticated-orcid":false,"given":"Steven","family":"Huang","sequence":"additional","affiliation":[{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-3234","authenticated-orcid":false,"given":"Torry A.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"},{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-2152","authenticated-orcid":false,"given":"Steven","family":"Idell","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"},{"name":"The Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1804-7993","authenticated-orcid":false,"given":"Guoqing","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.74"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81591-z"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/medsci6040110"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104706"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-146DR"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07044-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00067.2022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55176-w"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.02.014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3892\/br.2014.323"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160316"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205246109"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.448209"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.119909"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094873"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-21-0147"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092203"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.075"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24724-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3956"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00618-21"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0175OC"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2021.10.011"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0077OC"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.07.033"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12645"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/protex.2013.097"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-019-05682-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7113-8_2"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00468.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070196"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0252LE"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702750114"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.810286"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/art.23645"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2004.02.007"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.812166"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/ar.24238"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abk3067"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201502-088AW"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-03159-9"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00166.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T15:07:10Z","timestamp":1718636830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00166.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.1152\/ajpcell.00166.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00166.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"2023-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}