{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:49:57Z","timestamp":1791978597706,"version":"4.4.0"},"reference-count":119,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100004770","name":"University of Parma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004770","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100003887","name":"International Myeloma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:p> The transporter SLC38A5\/SNAT5 provides net influx or efflux of glutamine, asparagine, and serine. These amino acids are of particular metabolic relevance in several conditions. Changes in transporter expression or activity have been described in selected types of human cancers, where SNAT5 can mediate amino acid exchanges between tumor and stromal cells, thus providing a potential therapeutic target. This is the first review that recapitulates the characteristics and roles of the transporter in physiology and pathology. <\/jats:p>","DOI":"10.1152\/ajpcell.00169.2023","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T12:56:57Z","timestamp":1689598617000},"page":"C550-C562","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["The <i>SLC38A5<\/i>\/SNAT5 amino acid transporter: from pathophysiology to pro-cancer roles in the tumor microenvironment"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-1171","authenticated-orcid":false,"given":"Giuseppe","family":"Taurino","sequence":"first","affiliation":[{"name":"Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Parma, Italy"},{"name":"MRH\u2014Microbiome Research Hub, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5655-9984","authenticated-orcid":false,"given":"Martina","family":"Chiu","sequence":"additional","affiliation":[{"name":"Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano G.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Parma, Italy"},{"name":"MRH\u2014Microbiome Research Hub, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-2547","authenticated-orcid":false,"given":"Erika","family":"Griffini","sequence":"additional","affiliation":[{"name":"Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-2939","authenticated-orcid":false,"given":"Ovidio","family":"Bussolati","sequence":"additional","affiliation":[{"name":"Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Parma, Italy"},{"name":"MRH\u2014Microbiome Research Hub, University of Parma, Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15531"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.12.017"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175323"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696151"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1312-0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.05.003"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690743"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176156"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.07.007"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107964"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-020-00789-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1393-y"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2016.1207024"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1117-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2014.00061"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.07.012"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)97187-5"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.700534"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092151"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20693"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-017-1690-3"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01113-y"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20060026"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn151"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.05.001.2010"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13376"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00199"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81674-8"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4504"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20106"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01995.x"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.060293"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.4.974S"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.09.009"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523000902"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.162404"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.6.C1757"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00578.2007"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-007-0343-1"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.11.005"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.02.020"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.457242"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.011"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011676"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030203"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1731"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810199105"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2018.00045"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00135.2017"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.08.027"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2013.06.006"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101532"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111870"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001712RR"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282066"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13257"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115421"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i10.1024"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00114.2016"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00022"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1486"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1042\/bj2780105"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9931-1"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22924"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0275-5"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147569"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.11.011"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22386"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.5607\/en.2019.28.2.270"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0488"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2245"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73105"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075186"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-023-00449-w"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00114"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01158.x"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1993.1063"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020004041"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051899"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.991875"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-008-9046-x"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.10.003"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4518-z"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72930-7"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-3840-1"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00113.2006"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200403220-00001"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.01.036"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.05.01"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617066114"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005001"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3390\/ph14030216"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2496-y"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020235"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20210585"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030759"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002976"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0244-y"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.04.005"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-017-0255-y"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00031.2002"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-014-0756-x"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.974851"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91284-2"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn6491"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002229"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3272"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.10.011"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041099"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4464"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.02.020"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-00615-4"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3390\/pr9071170"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1515\/chem-2022-0239"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0483-3"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1125874"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00909-0"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00169.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T15:03:51Z","timestamp":1718636631000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00169.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,1]]},"references-count":119,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8,1]]}},"alternative-id":["10.1152\/ajpcell.00169.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00169.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,1]]},"assertion":[{"value":"2023-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}