{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:16:15Z","timestamp":1791443775495,"version":"4.3.3"},"reference-count":67,"publisher":"American Physiological Society","issue":"5","funder":[{"name":"Nippon Sport Science University","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H03332"],"award-info":[{"award-number":["21H03332"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K21771"],"award-info":[{"award-number":["20K21771"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K17452"],"award-info":[{"award-number":["23K17452"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:p> We explored the potential direct interplay between colon cancer cells (Colon-26) and skeletal muscle cells (C2C12 myotubes) employing a noncontact coculture experimental model. Our findings reveal that coculturing with Colon-26 cells substantially impairs the protein synthesis rate, concurrently instigating a metabolic shift toward glycolytic dominance in C2C12 myotubes. This research unveils critical insights into the intricate cellular cross talk underpinning the complex pathophysiology of cancer cachexia. <\/jats:p>","DOI":"10.1152\/ajpcell.00179.2023","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T08:10:36Z","timestamp":1711959036000},"page":"C1520-C1542","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Coculture with Colon-26 cancer cells decreases the protein synthesis rate and shifts energy metabolism toward glycolysis dominance in C2C12 myotubes"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-5343","authenticated-orcid":false,"given":"Yuki","family":"Tamura","sequence":"first","affiliation":[{"name":"Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"High Performance Center, Nippon Sport Science University, Tokyo, Japan"},{"name":"Sport Training Center, Nippon Sport Science University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2638-4930","authenticated-orcid":false,"given":"Karina","family":"Kouzaki","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Graduate School of Medical and Health Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0985-5825","authenticated-orcid":false,"given":"Takaya","family":"Kotani","sequence":"additional","affiliation":[{"name":"Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Department of Sports Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-5771","authenticated-orcid":false,"given":"Koichi","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Faculty of Medical Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Graduate School of Medical and Health Science, Nippon Sport Science University, Tokyo, Japan"},{"name":"Research Institute for Sport Science, Nippon Sport Science University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328300ecc1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2018.08.04"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2018.12.01"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(05)80001-3"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-020-00288-6"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18050986"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.690452"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.641514"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00738"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050695"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00025.2022"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1207"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847258"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.011"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.155147"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00028.2019"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00300.2010"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s10974-019-09510-4"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.861622"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90381.2008"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25359-z"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3892\/or.2019.7285"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2022-0005"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1314"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082003"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00204.2022"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00304.2021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/cpmo.21"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-62"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00494.2019"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2022-0462"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/s12576-022-00839-z"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3791\/63046-v"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59999-w"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200588R"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1992.tb19833.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.03.010"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00089.2019"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101540"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15041"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2009.09.017"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804304"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49624-w"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2020.113863"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.11.004"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00445"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2016.01.014"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2892-5"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00039.2012"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961127)68:5<637::AID-IJC14>3.0.CO;2-Z"},{"key":"B53","first-page":"415","volume":"51","author":"Gelin J","year":"1991","journal-title":"Cancer Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00041.2008"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.027"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073878"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.638411"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-09-0704"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20123-1"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-416618-9.00005-4"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-04303-x"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3652"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8224-x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15016"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00061.2018"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00641-2"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1177\/1559827617725283"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00179.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T14:44:52Z","timestamp":1718635492000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00179.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,1]]}},"alternative-id":["10.1152\/ajpcell.00179.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00179.2023","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]},"assertion":[{"value":"2023-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}