{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T09:48:04Z","timestamp":1785318484686,"version":"3.55.0"},"reference-count":105,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"Millenium Institute on Immunology and Immunotherapy","award":["ICN09_016"],"award-info":[{"award-number":["ICN09_016"]}]},{"name":"Millenium Institute on Immunology and Immunotherapy","award":["ICN 2021_045"],"award-info":[{"award-number":["ICN 2021_045"]}]},{"name":"Millenium Institute on Immunology and Immunotherapy","award":["P09\/016-F"],"award-info":[{"award-number":["P09\/016-F"]}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL143285"],"award-info":[{"award-number":["K24HL143285"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL136143"],"award-info":[{"award-number":["R01HL136143"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL142084"],"award-info":[{"award-number":["R01HL142084"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL114453"],"award-info":[{"award-number":["P01HL114453"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p> Matricellular proteins comprise a diverse group of molecular entities secreted into the extracellular space. They interact with the extracellular matrix (ECM), integrins, and other cell-surface receptors, and can alter matrix strength, cell attachment to the matrix, and cell-cell adhesion. A founding member of this group is thrombospondin-1 (TSP-1), a high molecular-mass homotrimeric glycoprotein. Given the importance of the matrix and ECM remodeling in the lung following injury, TSP-1 has been implicated in a number of lung pathologies. This review examines the role of TSP-1 as a damage controller in the context of lung inflammation, injury resolution, and repair in noninfectious and infectious models. This review also discusses the potential role of TSP-1 in human diseases as it relates to lung inflammation and injury. <\/jats:p>","DOI":"10.1152\/ajpcell.00182.2022","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T11:16:23Z","timestamp":1659352583000},"page":"C857-C865","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["The matricellular protein thrombospondin-1 in lung inflammation and injury"],"prefix":"10.1152","volume":"323","author":[{"given":"Mohammadreza","family":"Tabary","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atish","family":"Gheware","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n F.","family":"Pe\u00f1aloza","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Millennium Institute on Immunology and Immunotherapy, Santiago, Chile"},{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-6043","authenticated-orcid":false,"given":"Janet S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Acute Lung Injury Center of Excellence, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.130.3.503"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98545-5"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.01.012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.1.240"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.17.1.25"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-009-0074-2"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.004"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7487-y"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-009-0060-8"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.638536"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2012.01.006"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000496033"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7484-1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010091200"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/jci110646"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.13.9396"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1042\/bj3180959"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)90934-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005951200"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291x(92)91860-s"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.272re3"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.3.707"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/71517"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.13.7304"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.2.646"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.104.5.1413"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1989.tb15153.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.1.430"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809198200"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19165"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406267200"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.6.2351"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2000.109407"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/296069"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.6.2022.2022"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1021\/bi00116a036"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53157-4"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)80614-0"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1021\/bi00187a021"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.01.002"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605040200"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172304"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.3534"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200109098"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01268"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.95.1.351"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.4.998"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/srep03345"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12525350"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.93.2.343"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.1.79.79"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030705"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34336-3"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.6.3.245"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36175-6"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39635-7"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313560200"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020005382"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1684"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-131649"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1023\/a:1009018702832"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.10.002"},{"key":"B63","first-page":"153","volume":"2","author":"N\u00f6r JE","year":"2005","journal-title":"Oral Biosci Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/s0923-1811(02)00150-0"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81460-9"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.63"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.039"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0019OC"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2014.120"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.62"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2005.tb00367.x"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294447"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019654"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202104-1021OC"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.08.037"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.5.1125"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2014.07.006"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.05.009"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1983"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02441-2018"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2410OC"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0393-7"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0394-6"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77958"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00160"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004327"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9904047"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0449-x"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1410"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201705-1043SO"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018026286"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96914"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03336-20"},{"key":"B94","first-page":"1247","volume":"42","author":"Nagano T","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/srep09936"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003939"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102984"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006737"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.754702"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.623876"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.760504"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7992com"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.1.279-288.1991"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95823"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2006.04.003"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00182.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T15:11:58Z","timestamp":1718637118000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00182.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":105,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["10.1152\/ajpcell.00182.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00182.2022","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2022-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}