{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:45Z","timestamp":1791381225614,"version":"4.3.3"},"reference-count":34,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2400603"],"award-info":[{"award-number":["2023YFD2400603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p> The mitochondrial citrate shuttle is a crucial physiological process for maintaining metabolic homeostasis. In the present study, we found that inhibition of mitochondrial citrate shuttle (Slc25a1) could alleviate metabolic syndromes induced by high-fat diet (HFD) through remodeling hepatic protein acetylation modification. Briefly, Slc25a1 inhibition reduces hepatic triglyceride deposition by deacetylating Cpt1a and reduces glucose oxidative catabolism by acetylating Pdhe1\u03b1. Our study provides new insights into the treatment of diet-induced metabolic syndromes. <\/jats:p>","DOI":"10.1152\/ajpcell.00194.2024","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T08:02:13Z","timestamp":1722240133000},"page":"C737-C749","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet"],"prefix":"10.1152","volume":"327","author":[{"given":"Jun-Xian","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Qian","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fan","family":"Qian","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-5848","authenticated-orcid":false,"given":"Yuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Qiao","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Qiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-5313","authenticated-orcid":false,"given":"Zhen-Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Laboratory of Aquaculture Nutrition and Environmental Health (LANEH), School of Life Sciences, East China Normal University, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020141"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110391"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0101-z"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602606200"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0491-6"},{"key":"B6","doi-asserted-by":"publisher","unstructured":"Kasprzyk-Pawelec A, Tan M, Phua YL, Rahhal R, Mcintosh A, Fernandez H, Mosaoa R, Girgis M, Cheema A, Jiang L, Kroemer LF, Popratiloff A, Clarkson C, Kirmsa BM, Pearson GW, Glasgow E, Albanese C, Vockley J, Avantaggiati ML. Loss of the mitochondrial carrier, SLC25A1, during embryogenesis induces a unique senescence program controlled by p53 (Preprint). bioRxiv 2024.05. 31.549409,2024. doi:10.1101\/2023.07.18.549409.","DOI":"10.1101\/2023.07.18.549409"},{"key":"B7","doi-asserted-by":"publisher","unstructured":"Ohanele C, Peoples JN, Karlstaedt A, Geiger JT, Gayle AD, Ghazal N, Sohani F, Brown ME, Davis ME, Porter GA Jr. Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart (Preprint). bioRxiv 2023.05.22.541833, 2024. doi:10.1101\/2023.05.22.541833.37292906","DOI":"10.1101\/2023.05.22.541833"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105132"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30470-w"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0081-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.09.003"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1586\/era.10.62"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008708"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.105220"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa187"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3791\/3865"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.06.005"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1113\/JP279814"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.069"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.02.003"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.06.007"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04363-w"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2019.33.1_supplement.463.3"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.09.018"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04134-4"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04623-y"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.40.26157"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.11.1397"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9073"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.006"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-2571(01)00061-9"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077280"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.020"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00194.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:41:32Z","timestamp":1726144892000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00194.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1152\/ajpcell.00194.2024"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00194.2024","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]},"assertion":[{"value":"2024-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}