{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:40:28Z","timestamp":1790487628088,"version":"4.1.0"},"reference-count":78,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2014,1,15]]},"abstract":"<jats:p>\n                    Chronic heart failure (CHF) is characterized by decreased cardiac parasympathetic and increased cardiac sympathetic nerve activity. This autonomic imbalance increases the risk of arrhythmias and sudden death in patients with CHF. We hypothesized that the molecular and cellular alterations of cardiac postganglionic parasympathetic (CPP) neurons located in the intracardiac ganglia and sympathetic (CPS) neurons located in the stellate ganglia (SG) possibly link to the cardiac autonomic imbalance in CHF. Rat CHF was induced by left coronary artery ligation. Single-cell real-time PCR and immunofluorescent data showed that L (Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 and Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.3), P\/Q (Ca\n                    <jats:sub>v<\/jats:sub>\n                    2.1), N (Ca\n                    <jats:sub>v<\/jats:sub>\n                    2.2), and R (Ca\n                    <jats:sub>v<\/jats:sub>\n                    2.3) types of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels were expressed in CPP and CPS neurons, but CHF decreased the mRNA and protein expression of only the N-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels in CPP neurons, and it did not affect mRNA and protein expression of all Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel subtypes in the CPS neurons. Patch-clamp recording confirmed that CHF reduced N-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    currents and cell excitability in the CPP neurons and enhanced N-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    currents and cell excitability in the CPS neurons. N-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blocker (1 \u03bcM \u03c9-conotoxin GVIA) lowered Ca\n                    <jats:sup>2+<\/jats:sup>\n                    currents and cell excitability in the CPP and CPS neurons from sham-operated and CHF rats. These results suggest that CHF reduces the N-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel currents and cell excitability in the CPP neurons and enhances the N-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    currents and cell excitability in the CPS neurons, which may contribute to the cardiac autonomic imbalance in CHF.\n                  <\/jats:p>","DOI":"10.1152\/ajpcell.00223.2013","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T21:46:51Z","timestamp":1378936011000},"page":"C132-C142","source":"Crossref","is-referenced-by-count":40,"title":["Heart failure-induced changes of voltage-gated Ca\n                    <sup>2+<\/sup>\n                    channels and cell excitability in rat cardiac postganglionic neurons"],"prefix":"10.1152","volume":"306","author":[{"given":"Huiyin","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis G.","family":"Cornish","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Muelleman","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, Nebraska;"},{"name":"Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00027-4"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1991.tb01330.x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.041178"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00131.2003"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00214-2"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90385-9"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2958"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9190-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1987.252.3.H638"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2174\/157340311795677725"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/383431a0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr105"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9314-2"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2800"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80333-3"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.4.1890"},{"key":"B16a","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00311.2013"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2008.04.017"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq391"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9216-0"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201100236"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020825"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.023"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.061"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.026146"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000065187.80707.18"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828124ad"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0352-5_11"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1902"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.03.021"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(95)00105-0"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.4.1769"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2011.12.006"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90795-8"},{"key":"B34","first-page":"638","volume":"17","author":"Klein HU","year":"2010","journal-title":"Cardiol J"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000105721.71640.DA"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00214.2011"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00315.2011"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.01.011"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.12.001"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.15.1510"},{"key":"B42","first-page":"363","volume":"18","author":"Nooney JM","year":"1997","journal-title":"Trends Pharmacol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1097\/00044067-200407000-00008"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.760405"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199600002-00006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90167-L"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605233342101"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(87)90106-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114580"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.1.74"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-003-0805-2"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9209-z"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)91172-1"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.106.076083"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302291"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9179-1"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.07.016"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(92)90011-5"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.023"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00114.2010"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.015"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00754.2011"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22483"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.259.2.H536"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19960901)35:1<69::AID-JEMT6>3.0.CO;2-N"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.6.1959"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.68.5.1294"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019343"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019344"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.87.6.2867"},{"key":"B71","first-page":"7072","volume":"7","author":"Zheng C","year":"2005","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00073.2009"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(05)80020-9"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/0928-4257(93)90021-K"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/335360a0"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1126\/science.2868525"},{"key":"B77","first-page":"237","volume":"81","author":"Zucker RS","year":"1986","journal-title":"J Physiol (Paris)"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.00223.2013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T12:38:10Z","timestamp":1718627890000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.00223.2013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,1,15]]}},"alternative-id":["10.1152\/ajpcell.00223.2013"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.00223.2013","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718107751.793484296","asserted-by":"object"}]},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,15]]}}}